614 



ADVENTURES IN RADIOISOTOPE RESEARCH 



content of rabbit plasma. After the lapse of 15 min, they found 1% 

 decrease only, one of 12% after the lapse of 1 hr. The observation 

 that the inorganic P content of the plasma is reduced several hours after 

 administration of adrenaline was reported by Cori (1930) at an early 

 date. 



Effect of adrenaline on the rate of extrusion of intravenously injected 

 labelled phosphate from the circulation of the rabbit 



Figure 1 demonstrates the rate of disappearance of the intravenously 

 injected ^^F, 0.2 ml saline containing 0.1 mgm P as labelled phosphate, 



7000H o 



6300 



5600 



4900 



E 4200 



3 



o 



E 



a 



3500- 



^ 2800 



E 





< 



2100 



1400- 



700- 



■0-- c\f<arena',\ne iniected 



0--0--0 



""' I I I I 1 1 1 1 1 1 1 — 



5 10 15 20 25 30 35 40 45 50 55 60 

 Time in minutes 



Fig. 1. Effect of subcutaneous and intravenous injection of adrenaline 

 on the rate of extrusion of ^^p from the circulation of the rabbit. 



from the circulation both in a control rabbit and in a sister rabbit to 

 which 20 y of adrenaline were administered subcutaneously 17 min 

 before and again 26 min after ^^p ^as injected. 



Several experiments yielding similar results were carried out. 



