EFFECT OF ADRENALINE ON PLASMA AND TISSUE CONSTITUENTS 615 



The rate of disappearance of ^ap from the circulation is markedly 

 accelerated in all cases investigated. The phosphate which left the circu- 

 lation may remain in the interspaces into which it first penetrates, it 

 may return into the circulation or penetrate into the tissue cells, the 

 last mentioned process becoming more and mon^ predominant with 

 increasing time. The effect of adrenaline is most pronounced in the early 

 phase of the experiment. 



Effect of adrenoxyl on the rate of phosphate interchange between plasma 



and tissue 



Adrenoxyl, the monosemicarbazone of adrenochrome, is endowed 

 with a marked haemostatic action. It reduces the mean bleeding time 

 appreciably. We wished to investigate whether the rate of capillary 

 passage can be influenced by administration of adrenoxyl. While 1 mgm 

 of adrenoxyl administered to humans w as found to reduce the bleeding 

 lime by 30% — Roskam (1947) — 0.41 mgm of the drug given by sub- 

 cutaneous injection 1 to 3 hours before injecting the ^^p^ and the same 

 amount injected again intravenously to the rabbit shortly before the 

 administration of ^^p^ did not diminish the rate of passage of labelled 

 phosphate through the capillary wall, as seen in Fig. 2, which indicates 

 even a somewhat increased rate of passage. 



The adrenochrome Labaz was kindly presented to us by the Company 

 Labaz and by Kabi A. B. and, in an investigation most kindly carried 

 out by Prof. Ulf von Euler, was found to be free from adrenaline. 



Effect of Adrenaline on the Interaction of ^^Fe between Plasma and 



Tissue 



a) Disappearance of ^^Fe from the plasma of intraperitoneally injected 

 mice 



We tested the rate of disappearance of intraperitoneally injected 

 labelled FeClg from the plasma of the mouse. 10 mgm saline containing 

 0.04 microgram of Fe, and having an activity of 0.05 microcurie, were 

 injected both to controls and to 20 min earlier subcutaneously with 

 10 y adrenaline injected mice. The activity of the same volume of plasma 

 was compared 50 min after injecting the ^^Fe. As seen from Table 3, 

 adrenaline accelerates the disappearance of the ^^Fe from the circulation. 

 Table 4 contains data on the ^^Fe from the circulation. Table 4 contains 

 data on the ^^Fe uptake by the of organs of controls and adrenaline injected 

 mice. The liver of adrenaline injected mice takes up 1.9 times as much 

 ^^Fe than that of the controls. In another group of experiments a cor- 

 responding ratio of 1.8 was found. As 1 ml of plasma at the end of the 



