616 



ADVENTURES IN RADIOISOTOPE RESEARCH 



experiment had an activity corresponding to 860 counts per min a minor 

 part of the difference in the ^^Fe content of the organs of controls and 

 adrenahne injected mice (620 counts) may be due to a change in their 

 blood content. 



Table 3. — Ratio of the ^^Fe Con- 

 tent OF 1 GM OF Pooled Plasma of 10 

 Controls and 10 Adrenaline 

 Injected Mice 



Number of experiment 



Ratio of activity control: 

 adrenaline 



1 



2 

 3 



1.72 

 2.40 

 1.37 



Table 4. — Effect of Adrenaline on the Uptake of Intraperitoneally Injected 

 s^Fe by the Pooled Organs of 10 Mice Weighing 166 (C) and 176 (A) gm 



Organ 



Fresli weight in gm 



Dry weight in gm 



Counts/min 



given by 



total tissue 



Percentage 



change due 



to adrenaline 



Liver C . . 

 Liver A . . 



Spleen C . 

 Spleen A . 



Lungs C . . 

 Lungs A . 



Kidneys C 

 Kidneys A 



Muscles C 

 Muscles A 



6.8907 

 7.5583 



0.8765 

 0.5586 



1.2635 

 1.7735 



1.5907 

 2.0982 



2.2586 

 2.9593 



1.9105 

 2.1985 



0.2106 

 0.1361 



0.2831 

 0.3754 



0.4243 

 0.5868 



0.5704 

 0.7494 



4560 

 8690 



1685 



845 



711 



860 



514 



795 



800 

 306 



+ 90.7 



— 49.9 

 + 21 

 + 52 



— 61.7 



C denotes Controls. — A denotes adrenaline injected mice. 



b) Disappearance of ^ape from the circulation of rabbits into which 

 labelled iron-/5-globuline containing plasma was injected 



Flexner and assoc. (1948) have shown that after transfusing plasma, 

 to which labelled FeClg was added, in vitro to a guinea pig, the activity 

 of the plasma decreases first with a half-time of about 20 min but, 

 after the lapse of 20 — 30 min, a further decrease in the plasma activity 

 takes place with a half- value of about 3 hr. The initial rapid disappearance 

 of plasma activity is due to the exodus of ^^¥e which had no oportunity 

 to combine with jg^-globulin, while the remaining iron which had 



