EFFECT OF ADRENALINE ON PLASMA AND TISSUE CONSTITUENTS 



617 



opportunity to combine with that protein escapes at a much re- 

 duced rate. 



In a preliminary experiment we injected into the ear vein of a donor 

 rabbit 84 y of labelled iron and transfused 18 ml of whole blood after 

 the lapse of 1 hour to a sister rabbit. This procedure proved not to be 

 satisfactory, half of the transfused ^^Fe disappearing from the circulation 



7000-|Q 



6300- 



1400- 



Adrenoxyl injecTed 



=5^^^^^^=-^^ 



-i 1 I i" 



1 ^ 15 20 25 30 35 40 45 50 55 60 

 Time in minutes 



Fig. 2. Effect of subcutaneous injection of adrenoxyl on the rate of 

 extrusion of ^^P from the circulation of the rabbit. 



already in the course for 27 min, a further half in the course of 60 min 

 We then injected the donor rabbit with 1 y of iron only having an activity 

 of 0.9 micro C, and after the lapse of 1 hr transfused to a sister rabbit 

 10 ml of the plasma of the donor, securing at intervals plasma samples 

 from the receptor. The result of this and a second similar experiment is 

 seen in Fig. 5. 



The experiment was then repeated with receptor rabbits to each 

 of which 20 y of adrenaline were administered subcutaneously 52 min 

 and 33 min before transfusiner the activity plasma. 



