620 



ADVENTURES IN RADIOISOTOPE RESEARCH 



of 50/0 only. Thus, interchange between plasma sodium and the sodium 

 of the ear cartilage is a slow one. Injection of adrenaline increased the 

 last mentioned figure to 10%. 



We could not observe any acceleration of the exodus of 24Na from the 

 circulation under the action of adrenaline (cf. Fig. 4), in some of our 

 experiments (see Fig. 5) even a decrease in the rate of extrusion of radio- 

 sodium took place. An observation which may be taken to support the 

 interpretation of the accelerated disappearance of 32p and of ^^Fe of the 



150000 



E 



o 



o 



E 



100 000 



o 



50 000 - 



Conf'-o 



345 

 Time m minutes 



Fig. 5. Effect of injection of adrenaline on the rate of extrusion 

 of 24]Sra from the circulation of the rabbit. 



plasma under the effect of adrenaline as to be due to an enhanced inter- 

 action rate between the phosphate resp. iron present in the tissue cells 

 and that present in the interspaces. Dobson and his associates (1953) 

 found that the removal rate of sodium injected into an artery is greatly 

 accelerated by a systematic administration of adrenaline. 



The additional ^^Fe given off by the plasma under the effect of adre- 

 naline was found by us to find its way to a large extent into the liver 

 in which presumably an enhanced iron incorporation takes place under the 

 effect of adrenaline. Adrenaline was observed to produce hypoferemia 

 in dog by Gubler (1950) and in human by Bateman (1952). Adrenaline 

 was found to increase the oxygen consumption (Carr, 1934; Lund- 

 holm, 1949). 



From the activity of the injected plasma and of that of 1 ml plasma 

 secured after the lapse of 3 min follows a plasma content of the rabbit 



