622 ADVENTURES IN RADIOISOTOPE RESEARCH 



extravascular ^sp in a similar sense, though to a much restricted extent, 

 than does adrenahne. 



Adrenaline is known to bring about a violent increase in the outflux 

 of sodium through surviving frog skin, while to increase moderately- 

 only the influx of sodium (Ussing, 1952). A third compartment in which 

 sodium could accumulate was absent in these experiments. 



Gemzell and Samuels (1950) investigated the effect of ACTH on 

 the ^-P content of the plasma of rats injected intraperitoneally with 

 radiophosphate. They found the administration of the adrenocortico- 

 trophic hormone to diminish with 15°/o both the ^^P and ^^P content 

 of the plasma 50 min after the injection of radiophosphate. No increase 

 in the ^^P content of the liver was observed. In hypophysectomized rats 

 the 2-P content of the plasma, however, is conserved for a longer time 

 than in controls, as observed by Geschwind and assoc. (1950). 



Summary 



Administration of adrenaline to mice before intraperitoneal injection of ^^p 

 leads to a markedly increased rate of passage of the resorbed ^^p from the plasma 

 into the tissues. 



The rate at which ^ap leaves the circulation of the rabbit after intravenous 

 injection is accelerated to twice its normal value if a pharmacological dose of 

 adrenal was administered previously. 



Massive doses of adrenoxyl lead to a slightly increased rate of exodus of the 

 intravenously injected ^^p from the circulation of the rabbit. 



After intraperitoneal injection of ^^FeClj to mice ^^Fe leaves at a much enhanced 

 rate the plasma after administration of adrenahne. Much of the ^^Fe is recovered 

 in the liver. 



Labelled iron of ^*Fe-/9j-globulin transfused with the plasma of a donor rabbit 

 to a recipient rabbit, leaves the circulation if a pharmacological dose of adrenaline 

 is administered at a twice accelerated rate. 



In contrast to administration of adrenaline, exposure to X-rays strongly decrea- 

 ses the exodus of ^^Fe. 



Adrenaline does not accelerate the rate of exodus of intravenously injected 

 labelled sodium from the circulation of the rabbit. 



References 



K. Agneb, R. Bonnichsen and G. Hevesy (1950) Scand. J. Cliti. Lab. Inv. 



6, 261. 

 r. C. B. Bateman (1952), C T. Kloff and P. Miesfeld (1952) Blood 6, 1093. 

 C. J. Carr, J. E. Schmidt and W. Harpe (1934) J. Pharmacol. 50, 151. 

 C. F. CoRi and G. T. CoRi (1930) Proc. Sac. exp. Biol. 27, 558. 

 E. L. DoBSON, G. F. Warner, N. Pace, C. R. Finney and M. E. Johnston 



(1953) Fed. Proc. 12, No. 1. 

 L. B. Flexner and A. Gellhorn (1953) Amer. I. Obstet. Gynec. 43, 965. 

 L. B. Flexner, G. J. Vosburgh and D. B. Cowie (1948) Amer. J. Physiol. 153. 



503. 



