ISOTOPIC INDICATOKS IN HAEMATOLOGY 



643 



2 Konfrollen 



Physiol. Adrenalin- Dosis '*-^. 

 Phormokol. Adrenalin-Dosis'"''^ 







60 



120 

 min 



180 



240 



Fig. 4. The effect of adrenalin on the rate of escape of iron com- 

 bined in ^j globuUn from the plasma. 

 Kontrolle = control test. Physiol. AdrenaHn-Dosis = physiological 

 dosage of adrenahn. Pharmokol. Adrenalin-Dosis = pharmacological 

 dosage of adrenalin. Aktivitat in 1 ml plasma = activity per ml plasma. 



bined with protein but only after it has 

 been split off from the transferrin, and 

 it is very probable that the process de- 

 termining the rate of escape is the disso- 

 ciation of iron transferrin since the iron 

 ions or iron- containing radicals which are 

 split off penetrate the capillary walls with 

 the greatest ease. 



Plasma constituents such as phosphate, 

 for instance, which transfer extraordi- 

 narily quickly into the extracellular space, 

 often return before they "finally" leave 

 the plasma. This state is the more 

 quickly established when the phosphate 

 has the opportunity of finding an addi- 

 tional way of entering into the cell. The 

 reversion of phosphate ions into the plas- 

 ma is thereby made more difficult and its 

 ultimate disappearance from the blood 

 fluid is thus facilitated. If the disappea- 

 rance of phosphate from the plasma is 

 accelerated, e.g. by the injection of adre- 

 nalin, the effect must be ascribed in a 

 high degree to an accelerated entry of 

 the phosphate from the extracellular space 



• •Kon'i'oiie 



o_ o Noch Adrenal in- 



JfijeV'tion 





J 1 1 L. 



4 6 



mm 



Fig. 5. The effect of 

 adrenalin on the rate 

 of escape of labelled 

 sodium from the 

 plasma. 

 Kontrolle = control 

 test. 

 Nach Adrenalin- In jek- 

 tion = after injecting 

 adrenahn. Aktivitat 

 von 1 ml plasma = ac- 

 tivity per ml plasma. 



41^ 



