EFFECT OF X-RAYS ON NUCLEIC ACID IN THE RAT 



723 



Table 1. — Formation of Nucleic Acid in the Ohgans of Unirradiated Adult 



Rats in a Period of 2 lir 



Expt. no. 



80 



82 

 83 



84 



85 



88 

 93 

 97 



97 

 99 



103 



151 I 

 151 II 



Xo. of 

 rats 



Age aud sex 



Organ 



15 

 20 



1 



8 



1 year F 



8 3 months F 



8 1 year F 



10 months F 



15 months F 



6 months F 



10 7.5 months F 



15 11 months F 



11 months F 

 5 months F 



5 months F 



6 months F 

 3 months F 



Average valnes 



Activity of 1 mgrn of nucleic acid 



P as a percentage of the activity 



of 1 mgm of 



Free P in the 

 organ 



liver 



spleen 



kidneys 



liver 



liver 



kidneys 



liver 



kidneys 



liver 



spleen 



kidneys 



liver 



spleen 



liver 



kidneys 



liver 



spleen 



kidneys 



intestinal mucosa 



liver 



spleen 



kidneys 



intestinal mucosa 



spleen 



intestinal mucosa 



liver 



liver 



liver 



spleen 



kidneys 



intestinal mucosa 



0.052 



1.13 



0.119 



0.20 



0.034 



0.070 



0.031 



0.14 



0.0.54 



1.41 



0.19 



0.32 



3.57 



0.26 



0.15 



070 



3.19 



0-18 



5.05 



0.21 



0.25 



6.8 



2.9 



2.4 



0.13 



0.11 



Plasma P 



0.188 



0.218 

 0.12 

 0.069 

 0.077 

 0.049 

 0.13 

 0.064 

 1.00 

 0.18 

 0.12 

 2.2 

 0.30 

 0.14 

 0.103 

 2.51 

 0-26 

 2.40 

 0.18 

 1.29 

 0.21 

 2.6 

 1.97 

 0.87 

 0.31 

 0.13 



of most of the acid-soluble phosphorus compounds and phosphatides, 

 in the liver is very small and also that the spleen and especially the 

 intestinal mucosa are characterized by a high formation of nucleic 

 acid; Andreasen and Ottesen^^^ have shown recently that the meta- 

 bolism of nucleic acid in the thymus exceeds that in all other organs and 

 is twice as large in this organ as in the small intestinal mucosa. 



^ E. Andreasen and J. Ottesen, Acta Path. Microbiol. Scand. Suppl. 54. 

 (1944). 



46^ 



