820 ADVENTURES IN RADIOISOTOPE RESEARCH 



the liver (P < 0.04) and in the plasma fraction (P < 0.03). The mean 

 value in the percentage change in the ^^C uptake by all 17 fractions 

 enumerated in Table 8 works out to be 11.5, the mean deviation of this 

 value to ±5.3, thus P < 0.05. 



As much of the plasma proteins originates from the liver we have to 

 expect to find higher i^C figures in the plasma proteins of the irradiated 

 mice, which is actually the case. A markedly increased incorporation of 

 i^C into the brain phosphatides of rats, after administration of labelled 

 acetate was observed by Altman et alM^ 



Summary 



Following intraperitoneal injection of acetate labelled with "C in the carboxyl 

 group, total irradiation of 250 fed mice with 880 r administered in the course of 3 

 minutes leads to an increase in the mean value of i*C incorporation into total 

 tissue of hver, intestinal mucosa, muscles, kidney, lungs, brain, and plasma, into 

 total fats of liver, muscles, kidney and brain, into the proteins of liver, kidney 

 and brain of the mice investigated. 



(i) K. I. Altman, G. W. Casaeett, T. R. Noonan and K. Salomon, Fed. 

 Proc. 8, No. 1 (1949). 



