SPERM-EGG INTERACTING SUBSTANCES, III 55 



& Beiler in their rat experiments, Sieve said it was essential for 

 the men to take phosphorylated hesperidin, as well as the wom^en. 

 Sieve's claims should not be accepted until they have been in- 

 dependently confirmed, but this may be difficult, as in his paper 

 he does not reveal the structure of the phosphorylated hesperidin 

 used in his experiments, though he says that only one of the 

 possible phosphorylated compounds is efficacious. More recently 

 Chang & Pincus (1953) have repeated and failed to confirm Martin 

 & Beiler's results. They say (p. 275) that 'phosphorylated hesperi- 

 din does not inhibit fertilization when deposited into the Fallopian 

 tubes of rabbits at the time of sperm penetration, nor does it 

 inhibit ovulation, implantation, or normal development of the 

 embryo when administered intraperitoneally or orally to rats,' In 

 a 1% solution, phosphorylated hesperidin did, however, impair 

 the fertilizing capacity of rabbit spermatozoa, but, as Chang & 

 Pincus point out, such a high concentration would be unlikely to 

 be achieved after oral or intraperitoneal administration. 



