Eupatorium perfoliatum. 137 
this way it excites nausea, and keeps up the moisture of the skin. 
Its mere tonic effect is most easily ensured by giving in substance, 
from twenty grains to a drachm of the powdered leaves and flowers, 
from three to six times in the course of twenty-four hours. 
Of the beneficial administration of bone-set, in the treatment of 
yellow fever, medical records present us with well authenticated ac- 
counts. It was extensively used by some practitioners in this disease, 
at least as early as one thousand seven hundred and _ ninety-eight, 
when it was then rife in this city; and we have the authority of 
Dr. Barton to believe, that in that epidemic and others, it was used 
with much advantage. Pursh, the Botanist, likewise states, in a let- 
ter addressed to William Royston, Esq. inserted in the Medical and 
Physical Journal, that much benefit was derived from its use by him- 
self and others, during his stay in the neighbourhood of Lake Ontario ; 
where both the influenza and lake fever, the latter of which he says was 
similar to the yellow-fever, were raging among the inhabitants. In 
those cases it was used in decoction, and spirituous infusion. 
It appears by Dr. Anderson’s Thesis, that the bone-set was exten- 
sively used in the New York Alms-house, in the year one thousand 
eight hundred and twelve, in the treatment of intermittents, to the 
exclusion of the Peruvian bark, It was given either in decoction, or 
in powder. In the latter, in doses from twenty to thirty grains every 
second hour during the intermission, This practice the Doctor states, 
