Annals of The New York Academy of Sciences 



Volume XLVII, Art. 4. Pages 375-602 



December 15, 1946 



THE PHYSICO-CHEMICAL MECHANISM 

 OF NERVE ACTIVITY* 



By 



David Nachmansohn, Charles M. Berry, Oscar Bodansky, Frank 



Brink, Jr., Detlev W. Bronk, M. Vertner Brown, C. W. Coates, 



R. T. Cox, J. C. Eccles, Alfred Fessard, J. F. Fulton, R. W. 



Gerard, Alfred Oilman, D. E. Green, Joseph C. Hinsey, 



Rudolf Hober, Martin G. Larrabee, and 



Tracy J. Putnam 



CONTENTS 



PAGE 



Introduction to the Conference on Nerve Activity. By Tracy J. Putnam 377 



The Membrane Theory. By Rudolf Hober 381 



Chemical Mechanism of Nerve Activity. By David Nachmansohn 395 



An Electrical Hypothesis of Synaptic and Neuro-Muscular Tr.-vnsmis- 



siON. By J. C. Eccles 429 



Chemical Excitation of Nkrve. By Frank Brink, Jr., Detlev W. Bronk, 



AND Martin G. L.\rrabee 457 



Electrical Characteristics of Electric Tissue. By R. T. Cox, C. W. 



Coates, and M. Vertner Brown 487 



Some Basic Aspects of the .Activity of Electric Plates. By .4.. Fessard. . 501 



Physiological Function from the Standpoint of Enzyme Chemistry. By 



D. E. Green '. 515 



Cholinesterase. By Oscar Bodansky 521 



The Effects of Drugs on Nerve Activity. By Alfred Gilman 519 



The Recovery of Diameter and Impulse Conduction in Regenerating 



Nerve Fibers. By Charles M. Berry .\nd Joseph C. Hinsey 553 



Nerve Metabolism and Function. By R. W. Gerard 575 



Conclusion. By J. F. Fulton 601 



* This .series of papers is tlie result of a Conference on The Physico -Chemical Mechanism of 

 Nerve Activity held by the Section of Biologv of The New York Academy of Sciences, February 8 

 and 9, 1946. 



Publication made possible through a grant from the Conference EuWie&tiQjis Revolving Fund. 



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