452 ANNALS NEW YORK ACADEMY OF SCIENCES 



tion of rapid, repetitive, synaptic transmission. The postulated local 

 responses should be followed by refractory periods, but a possible ex- 

 planation is suggested. 



The testing of the hypothesis is shown, especially, to concern the 

 further investigation of the special electrical properties assumed for 

 the post-synaptic membrane ; also, the attempt to discover how far the 

 postulated electrical actions can account quantitatively for the post- 

 synaptic stimulation. It has been shown (above) that the observed 

 temporal course of the post-synaptic stimulation is satisfactorily ex- 

 plained. In addition, further pharmacological investigation is neces- 

 sary to test the explanation attributing a subsidiary role to acetyl- 

 choline transmission. It is evident that further work on the electrical 

 properties of membranes on local responses, and on ephaptic transmis- 

 sion, will provide additional tests of the hypothesis. 



BIBLIOGRAPHY 



1. Arvanitaki, A. 



1942. J. Neurophysiol. 5: 89. 



2. Barron, D. H., & B. H. C. Matthews 



1938. J. Physiol. 92:276. 



3. Bishop, G. H. 



1941. Ann. Rev. Physiol. 3: 1. 



3a. Bremer, F., V. Bonnet, & J. Moldaver 



1942. J. Arch. Int. Physiol. 52: 1. 



4. Bronk, D. W. 



1939. J. Neurophysiol. 2: 380. 



5. Brown, G. L. 



1937. J. Physiol. 89:438. 



6. Brown, G. L. 



1937. Physiol. Rev. 17: 485. 



7. Brown, G. L., H. H. Dale, & W. Feldberg 



1936. J. Physiol. 87:394. 



8. Buchthal, F., & J. Lindhard 



1939. 'i'lie Physiology of Striated Muscle Fiber. Munksgaard. Copenhagen. 



9. Buchthal, F., & J. Lindhard 

 1942. Act. Physiol. Skand. 4: 136. 



10. Cajal, S. R. 



1934. Trav. Lab. Rech. Biol. Madrid 29: 1. 



11. Clark, A. J. 



1936. Proc. Roy. Soc. London B 121 : 580. 



12. Cole, K. S. 



1941. J. Gen. Physiol. 25: 29. 



13. Cole, K. S., & R. F. Baker 

 1941. J. Gen. Physiol. 24: 535. 



14. Cole, K. S., & R. F. Baker 

 1941. J. Gen. Physiol. 24: 771. 



15. Cole, K. S., & H. J. Curtis 



1938. J. Gen. Physiol. 22: 37. 



16. Cole, K. S., & H. J. Curtis 



1939. J. Gen. Physiol. 22:649. 



