BODANSKY: CHOLINESTERASE 545 



It would also appear that these considerations will be of aid in 

 elucidating various physiological and physiopathological problems. It 

 has already been pointed out that the cholinesterase activity of the 

 serum is not necessarily an indicator of the cholinesterase activity of 

 the brain. Attempts to define the role of cholinesterase activity in the 

 transmission of nerve impulses must concern themselves with a study 

 of the properties of cholinesterase, at various loci of the nervous system, 

 and with a correlation of the in vivo alterations of the activity of these 

 cholinesterases, in response to administration of drugs or to other fac- 

 tors which have an effect on nerve activity. Finally, it would seem 

 that the compound, DFP, because of its capacity for decreasing mark- 

 edly, and apparently with a considerable degree of irreversibility, the 

 content of cholinesterase in various tissues, may serve as a most useful 

 tool for elucidating the role of cholinesterase and the factors which 

 influence its synthesis and degradation. 



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