LOUIS PASTEUR 3^7 



rabies. Seven received intra-venous inoculations, of which five have 

 died of rabies. Five were trephined and inoculated on the brain ; the 

 five have died of rabies. 



On the other hand, not one of the nineteen vaccinated dogs has 

 taken rabies. 



In the course of the experiments, on July 13, one of the refractory 

 dogs died in consequence of a black diarrhoea which had begun in the 

 first days of July. In order to ascertain whether rabies had anything 

 to do with it as the cause of death, its bulb was at once inoculated, 

 after trephining, into three rabbits and one guinea-pig. All four 

 animals are still to-day in perfect health, a certain proof that the dog 

 died of some common malady, and not of rabies. 



The second report of the Commission will be concerned with the 

 experiments made as to the refractoriness to rabies of twenty dogs 

 to be vaccinated by the Commission themselves. 



(M. Pasteur then announced that he had just received that same 

 morning the first report addressed to M. Fallieres by the Official Com- 

 mission on Rabies. It states that twenty-three refractory dogs were 

 bitten by ordinary inad dogs, and that not one of them had taken 

 rabies. On the other hand, within two months after the bites, 66 

 per cent, of the normal dogs similarly bitten had already taken the 

 disease.) 



November i, 1886. — New Communication on Rabies. — On Octo- 

 ber 26, 1885, I acquainted the Academy with a method of prophylaxis 

 of rabies after bites. Numerous applications on dogs had justified me 

 in trying it on man. As early as March i, 350 persons bitten by dogs 

 undoubtedly mad, and several more by dogs simply suspected of rabies, 

 had already been treated at my laboratory by Dr. Grancher. And in 

 consideration of the happy results obtained it appeared to me that it 

 had become necessary to found an establishment for anti-rabic vacci- 

 nations. 



To-day, October 31, 1886, 2,490 persons have received the pre- 

 ventive inoculations in Paris alone. The treatment was in the first 

 instance uniform for the great majority of the patients, notwithstand- 

 ing the different conditions presented by them as to age, sex, the 

 number of bites received, their seat, their depth, and the time which 

 had elapsed since the occurrence of the accident. It lasted ten days, 



