FIELD G 

 (Fi eld G-1) (Field G-2) 

 Column 27 Column 28 



PRETREATMENT OR 



EXPERIMENTAL STATE OF THE 



TEST ORGANISM OR OF THE ORGAN, 



TISSUE, OR CELL OF THE TEST ORGANISM 



Symbol Z only: 

 EXPERIMENTAL TREATMENT OF THE TEST 

 ORGANISM OTHER THAN TREATMENT 

 WITH THE TEST COMPOUND AND 

 COMPOUND CODED IN FIELD D 



ORGANISM, ORGAN, TISSUE, OR CELL IS EXPERIMENTALLY ADAPTED OR CONDITIONED to a 

 particular environment or situation (Pavlov dog, light-adapted cockroach, etc. ). Any exposures 

 to particular environments which do not result in specific adaptations are coded by Symbol 3 

 or 4. 



ORGANISM, ORGAN, TISSUE, OR CELL IS PRETREATED SURGICALLY (as in the states of Symbols 

 P, Q, and R), OR CHEMICALLY, OR BY ELECTRIC SHOCK, but (in contrast to Symbols P, Q, and 

 R) FOR ANY PURPOSE OTHER THAN ISOLATION OF THE ORGANISM AND AN ANATOMICAL 

 COMPONENT. Includes staining with dyes, surgical exposure of an organ for observation, 

 treatment for rendering an animal or muscular organ quiet or otherwise receptive to treatment 

 by the test compound, etc. (See the Key for a description of Symbols 2, P, Q, R, and B. ) 



ORGANISM, ORGAN, TISSUE, OR CELL IS EXPOSED TO AN ABNORMAL PHYSICAL OR CHEMICAL 

 ENVIRONMENT to which adaptation is not intended, preparatory for or during the test (high 

 atmospheric pressures, changes in 0^:002 ratio, temperature changes, changes in gravitational 

 pull, anaerobic culture conditions, etc. ). For radiation exposure, use Symbol 4. When the 

 test organism has become adapted to such an environment (prior to the test), Symbol 1 must be 

 used rather than Symbol 3. 



ORGANISM, ORGAN, TISSUE, OR CELL IS EXPOSED TO RADIATION which is not responsible for 

 the action coded in Field T-2. If radiation is administered as part of the treatment instead of 

 a pretreatment (i. e. , administered with the test compound so that both the chemical and radiation 

 factors are expected to be responsible for the response coded in Field T), Symbol Z must be used. 



ORGANISM IS EXPERIMENTALLY OR NATURALLY INFECTED. (For non-infectious pathological states 

 of the test organism, use Symbol 7, B, C, D, or E. ) If the organism responding as a whole to 

 the test compound has an infection that is restricted to a single organ, use Symbol and code 

 the organ in Field H-2; however, if the infection is restricted to a single tissue and Symbol 

 is used, the tissue can not be coded (neither in Field H-2 or I). (If the organism does not 

 respond as a unit to the test compound, but an organ [In Field H-I] or a tissue [in Field I] is 

 the unit responding to the test compound and having an infection, use Symbol N rather than 

 Symbol 5 or 0. ) If the organism has an organ or tissue implant, either normal or pathological, 

 use Symbol S. 



ORGANISM, ORGAN, TISSUE, OR CELL HAS BEEN MADE SENSITIVE OR HYPERSENSITIVE to the 

 test compound. (For a sensitive strain, use Symbol H. Use Symbol J for the state of induced 

 resistance to the test compound. ) 



ORGANISM IS IN AN EXPERIMENTAL PATHOLOGICAL STATE not otherwise specified by special 

 symbols- -5 (infectious disease), B (hormone deficiency), C (hormone excess), D and E 

 (dietary deficiencies), P (loss of an anatomical part), and S (bearing an implant). Symbol 7 

 includes all other non- infectious pathologies, including spontaneous tumors (but not implanted 

 tumors). Also, it includes general experimental stress either brought about by administration 

 of excesses of a specific material (e. g. , H^O, salt, CO^, etc. ), removal of an organ (to be 

 described in the written abstract and not coded in Field H-2), or a natural or unspecified 



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