FIEL DS G- 1 a nd G-2 

 Columns 27 and 28 



K PREGNANT 



L VIRGIN 



M ORGANISM, ORGAN, TISSUE, OR CELL IS CONGENITALLY ABNORMAL. 



N ORGAN OR TISSUE (SPECIFIED IN FIELD H-1 OR FIELD I) IS IN A PATHOLOGICAL STATE 



(including infectious and non-infectious pathological states and spontaneous tumors, but not 

 implanted tumors; if a tumor is implanted, use Symbol S). Use of this symbol includes indica- 

 tion of physiological stress on the organ; e. g. , the removal of one of a pair of organs, or part 

 of an organ, or an entire organ, or any other special pretreatment to produce the exaggerated 

 condition of in situ experimental stress on the organ specified in Field H-1 or the tissue 

 specified in Field I. The description of the specific pretreatment employed to produce stress 

 is not coded (e. g. , the organ removed to produce stress is not coded), but it is included in the 

 written abstract. (Any stress other than in situ is also eligible for being indicated by Symbol N. ) 

 The symbol is used when the organ in Field H- 1 or the tissue in Field I is infected, but only if 

 that infection is restricted to that organ or tissue or if the organ or tissue is excised (indicated 

 by Symbol R in Field G-1, placing Symbol N in Field G-2); if the infection is more general and 

 the organ or tissue is in situ, use Symbol 5. Similarly, Symbol N is used if the organ in Field 

 H-1 or the tissue in Field I has a non - infectious disease that is restricted to that organ or 

 tissue, but if the disease is more general and the organ or tissue is in situ, use Symbol 7. 



ORGAN (TO BE SPECIFIED IN FIELD H-2) IS IN A PATHOLOGICAL STATE DIFFERENT FROM THE 



STATE (NORMAL OR OTHERWISE) OF THE ORGAN CODED IN FIELD H-1. This organ may be an 

 organ to which the test compound is administered and which is not the specific organ responding 

 (a frequent use of Field H-2), but if Symbol is coded in Field G, it may be ANY pathological 

 organ, treated or not, which is not the organ coded in Field H-1. Use of Symbol includes 

 indicating any pretreatment to produce stress in an organ other than the organ in Field H-1. 

 Symbol is used when an organ other than the organ in Field H-1 is infected or has a non- 

 infectious disease or a spontaneous or implanted tumor. 



P ORGANISM (RESPONDING AS A WHOLE TO THE TEST COMPOUND) PREPARED FOR EXPERIMENTAL 



STUDY BY EXTIRPATING, CUTTING, A^lPUTATING. OR DESTROYING AN ORGAN, TISSUE, OR 

 FLUID (or by blocking or anesthetizing in situ a specific organ or tissue). The organ removed 

 or blocked in the organism is coded in Field H-2, though if the structure is a tissue, it can 

 not be coded either in Field H-2 or I. Use Symbol B when an endocrine gland is removed or 

 treated to produce a hormone deficiency. Use of Symbol P does not include removal of one of 

 a pair of organs or part of an organ to produce the exaggerated experimental condition of stress 

 In the organism, for which Symbol 7 is used. Consult the Key for a discussion of Symbols 2, 

 P, Q, R, and B. 



ORGAN OR TISSUE, IN SITU , (SPECIFIED IN FIELD H- 1 AS THE ORGAN, OR IN FIELD I AS THE 



TISSUE RESPONDING TO THE TEST COMPOUND) IS ISOLATED in some specific way from the 

 organism (denervation, circulatory obstruction, etc. ), isolated from a material it normally 

 processes (gastric or intestinal pouch), surgically isolated from one of its tissue components, 

 etc. This includes any in situ nerve-organ preparations. To code the fact that this organ 

 coded by Symbol Q is isolated from another organ or tissue by excision or destruction of that 

 second organ or tissue, code Field G-2 with Symbol P (assuming Symbol is in Field G-1) 

 and, if the structure is an organ, code it in Field H-2. Consult the Key for a discussion of 

 Symbols 2, P, Q, R, and B. 



R ORGAN, TISSUE, CELL, OR FLUID IS EXCISED (specified in Field H-1 or Field I as the organ or 



tissue responding to the test compound) for the purpose of isolating it from influences of all 

 other factors of the organism. Includes excised nerve-organ preparations. 



S ORGANISM, ORGAN, OR TISSUE RESPONDING TO THE TEST COMPOUND HAS AN ORGAN OR 



TISSUE (EITHER NORMAL OR PATHOLOGICAL) IMPLANTED IN IT. (E. g. , an organism with a 

 tumor implant is treated with a test compound for its analgesic action or its toxicity. ) Ex- 

 cluded are situations when the implant is an endocrine gland implanted to create a hormone 

 excess (Symbol C) or an organ implanted to produce a special stress (Symbol 7, N, or 0). If 

 an implanted organ is identified, it can be coded in Field H-2, but if the implant is a tissue, 



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