FIELD L 

 Column 44 



PRETREATMENT OR 



EXPERIMENTAL STATE OF THE 



HOST ORGANISM OR OF THE ORGAN, 



TISSUE. OR CELL (OF THE HOST ORGANISM) 



WHICH IS THE SITE OF THE 



PARASITE, NON-INFECTIOUS PATHOLOGY, 



OR TUMOR CODED IN FIELD E 



Symbol Z only: 



EXPERIMENTAL TREATMENT OF THE 



HOST OTHER THAN TREATMENT 



WITH THE TEST COMPOUND 



AND COMPOUND CODED IN FIELD D 



HOST (OR ORGAN, TISSUE, OR CELL SITE OF THE PATHOLOGY) IS EXPERIMENTALLY ADAPTED 

 (i. e. , conditioned) to a particular environment or situation (to facilitate its acceptance of the 

 test organism or test compound, e. g. ). Any exposure to particular environments which do not 

 result in specific adaptations , are coded by Symbols 3 or 4. 



HOST (OR ORGAN, TISSUE, OR CELL SITE OF THE PATHOLOGY) IS PRETREATED SURGICALLY (as 

 in the states of Symbols P, Q, and R), CHEMICALLY, BY ELECTRIC SHOCK, ETC. , but (in 

 contrast to Symbols P, 0, and R) for any purpose other than isolation of the host and an 

 anatomical unit. Includes staining with dyes, surgical exposure of an organ only to facilitate 

 observation, treatment for rendering an animal host quiet or otherwise receptive to treatment 

 with the test compound. Also, special pretreatment for making the host more receptive to 

 introduction of an infectious organism or the chemical treatment, such as special diet, removal 

 of hair, feathers, or scales, skin laceration, etc. 



HOST (OR ORGAN, TISSUE, OR CELL SITE OF THE PATHOLOGY) IS EXPOSED TO AN ABNORMAL 

 PHYSICAL OR CHEMICAL ENVIRONMENT, preparatory for or during the test, to which adaptation 

 is not intended . (Included are high atmospheric pressures, changes in 0^:002 ratio, 

 temperature changes, changes in gravitational pull, anaerobic culture conditions, etc. ) For 

 radiation exposure, use special Symbol 4. When the host has become adapted to such an 

 environment (prior to the test), Symbol 1 must be used rather than Symbol 3. 



HOST (OR ORGAN, TISSUE, OR CELL SITE OF THE PATHOLOGY) IS EXPOSED TO RADIATION which 

 is not intended as treatment or part of the treatment for the parasite or pathology or tumor coded 

 in Field E. If radiation is administered as part of the treatment of the host instead of a pretreat- 

 ment (i. e. , administered with the test compound so that both the chemical and radiation factors 

 are expected to be responsible for the response coded in Field T), Symbol Z must be used. 



HOST IS EXPERIMENTALLY OR NATURALLY INFECTED or parasitized with an organism other than 

 the parasitic or infectious organism specifically treated by the test compound, or in addition to 

 the non-infectious pathology or tumor being specifically treated. (For non- infectious pathological 

 states of the host, other than the pathology or tumor coded in Field E, use Symbol 7, B, C, D, 

 or E). If this incidental infection is restricted to a single organ , use Symbols N or 0. 



HOST (OR ORGAN, TISSUE, OR CELL SITE OF THE PATHOLOGY) HAS BEEN MADE SENSITIVE OR 

 HYPERSENSITIVE to the test compound. (For a host strain sensitive to the test compound, use 

 Symbol H. Use Symbol J for the state of induced resistanc e to the test compound. ) 



HOST IS IN AN EXPERIMENTAL PATHOLOGICAL STATE other than the pathology coded in Field E 

 and not otherwise specified by special symbols--5 (infectious disease), B (hormone deficiency), 

 C (hormone excess), D and E (dietary deficiencies), P (loss of an anatomical part), and S 

 (bearing an implant). Symbol 7 is used for all other non-infectious pathologies (other than the 

 pathology in Field E), including spontaneous tumors (but not implanted tumors). Also, it includes 

 general experimental stress either brought about by administration of excesses of a specific 

 material (e. g. , H2O, salt, CO^, etc. ), or removal of an organ (to be described in the written 



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