FIELD O 

 Column 49 



(1) DOSAGE FREQUENCY 



(2) SEQUENCE OF ADMINISTRATION OF 



THE SECONDARY COMPOUND 

 AND THE TEST COMPOUND 



1 Single administration, when a continuous supply to the test organism is not insured. (No 



entry in Field P. ) 



2 Single administration, when a continuous supply to the test organism is insured. (Duration 



of application of the dose is specified in Field P. ) Ad libitum administration. (Consult the 

 Key for a discussion of the use of Symbol 2. ) 



3 Repeated doses at intervals more frequent than specified below. (Duration of treatment 



specified in Field P. ) 



4 Hourly administration of the dose in Field M and/or N. (Duration of treatment specified in 



Field P. ) 



5 Three-times-daily administration of the dose in Field M and/or N. (Duration of treatment 



specified in Field P. ) 



6 Twice-daily administration of the dose in Field M and/or N. (Duration of treatment specified 



in Field P. ) 



7 Daily administration of the dose in Field M and/or N. (Duration of treatment specified in 



Field P. ) 



8 Every-other-day administration of the dose in Field M and/or N. (Duration of treatment 



specified in Field P. ) 



9 Every-three-days, or less frequent, administration of the dose in Field M and/or N. (Duration 



of treatment specified in Field P. ) 



II 



Test compound given before the secondary compound. (The time period is specified in Field P 



and the secondary compound is specified in Field D. ) 



# Test compound given after the secondary compound. (The time period is specified in Field P 



and the secondary compound is specified in Field D. ) 



* Test compound given simultaneously with the secondary compound. (The secondary compound 



is specified in Field D. No entry is made in Field P, unless one of Symbols 1 through 9 is 

 also coded in Field O, in which case Field P is coded with the duration of treatment with the 

 test compound. ) 



132 



