FIELD S-1 



FIELD S-2 



FIELD S-3 



Columns 54, 55, and 56 



ROUTE AND MANNER OF ADMINISTRATION OF: 



(1 ) INOCULUM OR IMPLANT (FIELD S- 1 ) 



(2) SECONDARY COMPOUND (FIELD S-2) 



(3) TEST COMPOUND (FIELD S-3) 



Any symbol of this list not otherwise marked may be used for coding Field S-1, Field S-2, or 

 Field S-3. Certain symbol definitions relate in a specific manner to Fields S-2 and S-3 and those are 

 designated in each case by a separate definition for Field S-1 (Symbols 8, B, E, G, J, and R) or by a 

 notation that the symbol as it is defined is not applicable to Field S-1 (Symbols C and M). 



FIELD S-3 ONLY: Certain of the items of this list can employ Field H-2 to indicate more speci- 

 fically the route of the test compound . In the case of each of these items with which Field H-2 is used, 

 this is indicated at the end of that definition. (There is no similar way by which the manner of admin- 

 istration can be more specifically coded, except that the information about the state of the test compound 

 coded in Field A often contributes to an understanding of the coded manner of administration. However, 

 none of the symbols of Field S-3 make special reference to coding in Field A. This is discussed in 

 Division 4 of the section on Specific Directions and Explanations for Field S-3, in the Key. ) 



Note that certain of the symbols (0, 1 through 9, A through I, P and Q, and S through Z) represent 

 routes and methods of application directly to the organism or some part of the organism. Symbols J 

 through and Symbol R represent methods by which application is to the environment as well as, or 

 instead of, to the organism so that the organism receives- -or may receive- -all or part of the material 

 from the environment (with the possible exception of Symbol L, since the organism in that case is 

 removed from the treated environment). This latter method most frequently permits less control of the 

 quantity the organism receives, but often represents a more natural method for evaluation of the chemical 

 for use in practical field application. 



When the words "dose" and "compound" (or "chemical") appear in these definitions, they should 

 be interpreted, for Field S-2, as "dose of the secondary compound" and, for Field S-3, as "dose of the 

 test compound"; for Field S-1, however, substitute "quantity of" and "inoculum" for the expressions 

 "dose of" and "compound". 



Parenteral. (Any manner of administration by parenteral route. ) This symbol is to be used only 

 when the parenteral route is not more specific, such as intravenous, subcutaneous, etc. 

 (Opposed to parenteral are the enteral [alimentary tract] routes. Symbols 1, 2, 3, 4, and T. ) 



Oral route, method unspecified. (For specific methods of oral administration, see Symbols 2 

 and 4. For other enteral routes, use Symbol 3 or T. ) 



Oral route, administration of a measured dose by feeding or placing in the oral cavity the free 

 compound, undiluted or mixed with food or other materials. (For administration techniques 

 whereby the compound is not free to contact the oral parts, use Symbol 3. For unmeasured 

 doses by either oral method, use Symbol 4. ) 



Postoral enteral route by which is administered a measured dose by by-passing the oral cavity; 

 examples; stomach tube, capsule (even when the capsule is taken orally and voluntarily 

 swallowed), duodenal tube, or other means (including surgical) of introduction into a specific 

 part of the alimentary lumen (except by anal approach, Symbol T). (Use Symbol 3 also for 

 injection of a measured dose into the lumen of an exteriorized intestinal loop. ) (For unmeasured 

 doses, use Symbol 4. ) Field S-3: Field H-2 may be used to specify the part of the alimentary 



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