FIELDS S-1, S-Z, and S-3 

 Columns 54, 55, and 56 



the developing offspring rather than indirectly through its parent, use an appropriate symbol 

 other than Symbol 0. If administration is by injection directly to the embryonic membranes, 

 use Symbol S. ) Field S-3: The parental structure to which the test compound is administered 

 (if known) should be coded in Field H-2, the developmental stage of the offspring at the time 

 of application should be coded in Field F, and the dose given to the parent should be coded in 

 Fields M and N (unless the dose to which the embryo is exposed is determined, in which case 

 that dose should be coded in Fields M and N with Symbol # in Columns 46 and/or 48). See 

 Field F, Key, Specific Directions and Explanations, Division 3, paragraph 3. 



P Administration to and through meninges and to the central nervous system, manner unspecified 



(ordinarily by injection). Examples: intramedullary, subdural, intraspinal, intracranial, 

 intrathecal, intracisternal. For intracerebral application, use special Symbol V. Field S-3: 

 The specific structure to which the test compound is applied should be coded in Field H-2 if 

 that organ is not the organ specifically responding coded in Field H- 1. 



Q Administration intra-sinusoidal to paranasal sinuses , manner unspecified 



R Application to a single point on or in an environmental medium through which the applied 



chemical diffuses to establish a diffusion gradient to which the test organism (present at the 

 time of application or introduced subsequent to application) is exposed. Example: Oxford 

 Plate Technique. (When such an application results in no gradient [i. e. , results in complete 

 mixing with the medium], only Symbol N can be used. ) Field S-1: Application of the inoculum 

 to a single restricted area on a culture medium over or through which it subsequently grows. 



S Injection directly into embryonic membranes of the developing organism. Example: injection 



into allantois of chick embryo. Field S-3: The specific embryonic membrane to which the test 

 compound is applied can be coded in Field H-2, if that membrane is not the specifically 

 responding structure coded in Field H-1. 



T Rectal or colonic administration. Example: colonic lavage. 



F Intra-osseous injection. Field S-3: The specific bone structure to which the test compound is 



applied can be coded in Field H-2, if that structure is not the specifically responding structure 

 coded in Field H-1. 



H Intra-pleural injection 



U Vaginal administration 



V Intra- cerebral administration 

 W Intra- testicular 



X Intra-ocular 



Y Intra- tumoral 



Z Intra-organal (organ other than specified above and other than introduction directly into any 



part of the alimentary lumen [Symbols 3 or T]). Field S-3: Use Field H-2 to name the specific 

 organ to which the test compound was applied if that organ is not the specifically responding 

 structure coded in Field H-1. 



140 



