FIELD T-1 

 Column 57 



SPECIFIC ACTION OF THE TEST COMPOUND 



ON THE BIOLOGICAL STATE, QUALITY, OR PROCESS 



CODED IN FIELD T-2 



The test compound: 



1 Increases, stimulates, facilitates, lowers threshold (for the physiological phenomenon of 



Field T-2), enlarges. 



Speeds, accelerates, increases rate or progress (of the physiological process or pathological 

 condition of Field T-2). 



2 Decreases, depresses, raises threshold (for the physiological phenomenon of Field T-2), 



reduces, partially inhibits, partially blocks, partially stops, partially prevents. 

 Slows, retards, delays, decreases rate or progress (of the physiological process or 



pathological condition of Field T-2). 

 (Note; When the test compound causes complete stoppage or completely inhibits or prevents 



the physiological process or pathological condition of Field T-2, use Symbol 3. ) 



3 Stops, blocks, inhibits (completely), prevents, abolishes, cures. 



(Note: This symbol indicates complete stoppage of a process. However, Symbol 3 can never 

 be used to indicate the complete kill of a group of organisms, i. e. , the complete reduction 

 of the number of organisms; the test compound's causing death is indicated in Field T-1 only 

 by Symbol 7 and the fact that the compound caused 100% kill is indicated only by appropriate 

 coding in Field Y. ) 



4 Increases, speeds, etc. (see Symbol 1) and subsequently decreases, slows, etc. (see Symbol 



2). I. e. , the biological condition or process of Field T-2 is first increased or speeded then 

 is reversed to be decreased or slowed, as a complex response to a single administration of 

 the test compound. 



5 Decreases, slows, etc. (see Symbol 2) and subsequently increases, speeds, etc. (see 



Symbol 1). I. e. , the biological condition or process of Field T-2 is first decreased or 

 slowed then is reversed to be increased or speeded, as a complex response to a single 

 administration of the test compound. 



6 Makes irregular, arrythmic, acyclic, fluctuating. 



(Note: Symbol 6 suggests disruption of control, due to the test compound, causing the 

 biological process or behavior to proceed in a fashion more irregular than can be described 

 by Symbols 1, 2, 3, 4, or 6. Use Symbol 6 also when the test compound effect is to disrupt 

 a balanced biological system or process [e. g. , acid-base balance, blood cell proportion, 

 nitrogen balance]; Symbols 1, 2, 3, 4, or 5 would not appropriately express the balance 

 disruption. ) 



7 Produces, causes, does, initiates, induces, brings about (also, stimulates, in the sense of 



initiating, not in the sense of accelerating for which Symbol 1 is used). 

 (Note: Use Symbol 7 in the passive sense, when the test compound "undergoes" some 

 alteration [Field T-2 Symbol series FE--] and when the test compound "is" excreted, 

 synthesized, stored, absorbed, etc. [Field T-2 Symbols FF-B, FAB, FBB, FOB, and FIB]. 

 Use Symbol 7 also when the test compound "permits" or "initiates" a secondary compound's 

 alteration, excretion, uptake as a nutrient, synthesis, etc. [Field T-2 Symbols FE--, FF--, 

 F6--, etc. ]. ) 



8 Synergizes or potentiates the biological response (identified only as a biological condition or 



process in Field T-2) to the secondary compound (coded in Field D). Use Symbol 8 also to 

 indicate that the test compound is essential for (permits or initiates) the action of a secondary 

 compound (coded in Field D). However, when the test compound permits or is essential for 

 the synthesis , alteration , or metabolism of a secondary compound (Field T-2 Symbols FE--, 

 FF--, F6-, F8-, etc.), use Symbol 7 instead of Symbol 8. 



(Note: When Symbol 8 is used. Field T-1 can not indicate the synergized action of the secondary 

 compound; always include the secondary compound's action synergized in the written abstract 

 portion of Field T-2. ) 



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