FIELD T-2 



34 

 35 



41 



411 



4111 



4112 



4113 



844 



418D 



412 



413 



414 



change. (Use with Symbol 1 or 2 of 



Field T-1.) 4161 



Somatic mutation 4165 



Anatomical change of the organism, 4166 



unspecified, due to a specific genetic 

 mutation FA24 



Pathological states involving abnormal 874 



growth and differentiation or degen- 8771 



eration 8781 



Abnormal morphological states, exclusive 

 of tumors and unspecified concrements 8531 



and casts (see Symbols 421, 43, etc. ) FA24 



Atrophy, including toxic atrophy. (Use 417 



Symbol 411 only if the atrophy is not 

 specified according to a general type 

 indicated by Symbol 41 1 1, 4112, etc.) 

 For abnormally diminutive morphological 

 structures due to faulty development 

 (e.g., hypoplasia), use symbols of the 

 28-- or 2A-- series. 



Simple atrophy 



Pyknosis 



Inflammatory atrophy 



Cytolysis 



Histolysis 



Hypertrophy (a process or state of the 

 component cells' enlarging or being 

 enlarged rather than an abnormal in- 418 



crease in number of cells) 4181 



Hyperplasia other than tumors (Symbol 418A 



43--, 44--, etc. ). A process or state 418B 



of the component cells' increasing in 418J 



number, yet essentially retaining their 418K 



normal character. 4182 



Altered form. Abnormal form of the 4183 



organism or the structure in Field H or 

 I, due to abnormal growth of some part 4185 



or parts of the organism or structure. ) 4186 



Monstrosity. Abnormal caste form 

 (e. g. , abnormal body form of the indi- 4187 



vidual of a bee or ant colony). Abnormal 4188 



type of colony (fungal or bacterial 418F 



colony form, e.g.). Use Symbol 414 418G 



for abnormal form of plant parts, such 4189 



as leaf roll, petal roll, abnormal leaf 418A 



or petal shape, or abnormal leaf or 418B 



petal pattern. If the change is a plant 

 "curvature" due to unequal cell elon- 

 gation, use Symbol 2211 rather than 418D 

 414. 844 



418E 



Texture change, unspecified (abnormal 

 thickness, stiffness, harshness, elas- 

 ticity). For specific texture changes, 

 use a specific symbol such as 4151 

 (abnormal hardness, abnormal softness, 

 abnormal thickness, etc. ) 



Abnormal hardening; sclerosis 



Discoloration (different hue or intensity 

 than normal to the individual or variety). 

 See also Symbols 8771, FA24, etc. 



Russeting (of fruits) 



Chlorosis, unspecified as to cause 



Abnormal increase in depth of green 

 color of plants 



Icterus (with bile coded in Field D) 



Cyanosis 



Flushing, erythema (skin) 



Pallor due to blood withdrawal from the 

 skin 



Pallor due to anemia 



Melanosis 



Lesion (e. g. , a wound or mechanical in- 

 jury or toxic lesion), destructive pro- 

 cess or state other than those indicated 



by other symbols of the 4 series and 



by symbols of the 113- and 114- series. 

 This symbol is generally used only for 

 symptoms (of a disease coded in Field 

 E) treated by the test compound, rather 

 than injury caused by the test compound. 

 Symbol 417 is used for destructive in- 

 jury that is unspecified yet can not be 

 indicated by Symbol 41 because the 

 latter indicates only unspecified change 

 including hypertrophy as well as des- 

 tructive change. 



Degeneration, unspecified 



Necrosis, unspecified 



Necrosis, liquefactive 



Necrosis, coagulative 



Necrosis, hemorrhagic 



Necrosis, caseous 



Caries 



Cloudy swelling (parenchymatous 

 degeneration) 



Hydropic degeneration 



Fatty degeneration and/or fatty 

 infiltration 



Hyaline degeneration 



Amyloid degeneration 



Mucinoid degeneration 



Fibrinoid degeneration 



Cirrhosis 



Necrosis, liquefactive 



Necrosis, coagulative; infarction; throm- 

 botic or embolic necrosis, unspecified. 

 (See Symbol series 87--. ) 



Histolysis or unspecified autolysis 



Cytolysis 



Necrobiosis 



150 - 



