FIELD T-2 

 Columns 58, 59, 60, and 61 



The following symbols of the FE-- series 

 are to be used for coding specific alter- 

 ations of the test compound . They are 

 also used for coding specific alterations 

 of secondary compounds when that alter- 

 ation is affected (increased, decreased, 

 stopped) by the test compound or when 

 the test compound is essential for the 

 secondary compound's alteration. Fi- 

 nally, they are used for coding specific 

 alterations of a third compound which 

 are affected by a secondary compound 

 when that effect of the secondary com- 

 pound is affected (synergized, antagon- 

 ized, etc. ) by the test compound. In 

 the case of each of the last two uses 

 of symbols of the FE-- series. Symbol * 

 must be coded in Column 61. The spe- 

 cific directions for the coding procedure 

 when these symbols are used are very 

 important. They are included only in the 

 Key which must be consulted to assure 

 coding Fields T- 1 and D correctly with 

 these symbols. 



FE Alteration, unspecified. (Symbol FE can 



be used to indicate that the test 

 compound is a precursor for [and altered 

 to] a specific biological product coded 

 in Field D. ) 



FEl Detoxification, unspecified 



FEZ Oxidation, unspecified (Symbol FEZ is 



not used for C-C bond cleavage. ) Use 

 Symbol FEA for glucose oxidation, etc. 



FEZl Aliphatic hydrocarbon —^ alcohol 



FEZ2 Alcohol — ^ aldehyde or ketone 



FE23 Aldehyde — acid 



FEZ4 Alcohol — acid 



FE25 Dehydrogenation of an aliphatic chain 

 or carbocyclic ring (unsaturation) 



FEZ6 Peroxidation 



FE27 Aromatic hydrocarbon — ^ phenol 



FEZ8 Phenol — - quinone 



FE29 Sulfhydryl -^ sulfide 



FEZJ S-O bond formation or oxidation (e. g. , 

 SO4 from SO3, sulfone formation) 



FEZK Valence change (e.g., ++ to+++), for 

 elements other than N, O, P, and S 



FEZL p-oxidation 



FEZM Omega oxidation 



FE3 Reduction, unspecified 



FE31 Alcohol aliphatic hydrocarbon 



FE3Z Aldehyde or ketone — ► alcohol 



FE33 Acid — ^ aldehyde 



FE34 Acid — alcohol 



FE35 Hydrogenation of an aliphatic chain 

 (saturation) 



FE3 6 Hydrogenation of an aromatic ring 

 (loss of aromaticlty) 



FE37 

 FE38 

 FE39 

 FE3J 



FE3K 



FE4 

 FE41 



FE42 



FE43 



FE44 



FE45 



FE5 



FE51 



FE5Z 



FE53 



FE6 



FE61 



FE6Z 



FE63 



FE7 



FE71 



FE7Z 



FE73 



FE7 4 



FE7 5 



FE76 



FE77 



FE78 



FE7 9 



FES 



FE81 



FE8Z 



FE83 



FE84 



FE9 



FE91 



FE9Z 



FEA 



FEAl 



FEAZ 



FEA3 

 FEA4 

 FEA5 

 FEA6 

 FEA7 



Quinone — ^ phenol 



Imino — - amino 



Sulfide — sulfhydryl 



Reduction of S-O compounds (e. g. , 



SO4 — SO3) 

 Valence change (e.g. +++ to ++) for 



elements other than N, O, P, and S 

 Conjugation, combination, unspecified 

 Conjugation with glucuronic acid or 



other sugar acid 

 Conjugation with glycine or other amino 



acid 

 Conjugation with sulfate 

 Formation of mercapturic acids 

 Detoxification with glutamine 

 Acylation, unspecified 

 Acetylation 

 Acylation with other aliphatic acids 



(e. g. , formylation) 

 Acylation with aromatic acids 



(e. g. , benzoylation) 

 Esterification, unspecified 

 Esterification with phosphoric acid 

 Esterification with ATP, ADP 

 Esterification with CoA 

 Hydrolysis, unspecified 

 Hydrolysis of a simple ester 

 Hydrolysis of a peptide bond 

 Hydrolysis of a sulfur-carbon bond 



(e. g. , Acetyl coenzyme A) 

 Deacylation (e.g. , hydrolysis of 



acetylcholine) 

 Deconjugation (e.g. , hydrolysis of 



glucuronides) 

 Hydrolysis of phosphate ester linkages; 



dephosphorylation (e. g. , Glucose-6- 



PO4) 

 Hydrolysis of pyrophosphate linkages 



(e. g. , ATP, ADP) 

 Hydrolysis of N-P linkages (e.g. , 



phosphocreatine) 

 Hydrolysis of acetal linkages (e.g. , 



sucrose) 

 Deamination, unspecified 

 Oxidative deamination 

 Transamination 

 Deamidation 

 Deamidination 

 Binding 

 Chelation 

 Protein-binding 

 Degradation, unspecified 

 Degradation to unidentified products 

 Carbon bond cleavage; loss of carbon 



atoms 

 Decyclization, ring cleavage and opening 

 Ring contraction 

 Decarboxylation 

 Oxidative decarboxylation 

 Depolymerization 



160 



