FIELD W 

 Column 68 



A. QUAUFICATION OF THE NEGATIVE AND 

 POSITIVE CHARACTER OF TEST RESULTS 

 AND QUAUFICATION OF THE CODED DOSE 



B. INFORMATION ABOUT SLOPE OF THE 

 DOSAGE-RESPONSE CURVE 



Negative Response 



The following two symbols, J and K, are used only when the response coded in Field T has not 

 been produced by the test compound. Thus, when these symbols are used, Field X must be coded with 

 Criterion 01, 02, or 62 and Field Y must be coded with Symbol 1. With any other coding in Fields X 

 and Y, only Symbol L, M, N, 0, or P can be used in Field W. 



J The response does not occur at the coded dose. (When the response is "death", refer to the 

 final statement in parentheses, below. ) 



The maximum tolerated dose level has not been determined; the coded dose is not known to 

 be the MTD. 



The dose administered (the coded dose) has not been determined to be the largest dose that 

 could be administered. 



The compound is not demonstrated to be inactive below the toxic level (or other level) that 

 prohibits administration of larger doses. 



(If "death" is coded in Field T-2 and is not caused by any doses administered, use Symbol J 

 if it seems that administration of a larger dose is possible and therefore death at a larger 

 dose might be possible. I. e. , use Symbol J only if it seems not to have been demonstrated 

 that the test compound could not cause death. When Criterion 21, maximum tolerated dose, 

 is used in Field X, the dose coded is the dose not causing the toxic effect or death coded in 

 Field T-2, for which reason there may be temptation to use Symbol J [or K] in Field W; do not 

 use Symbol J [or K] when Criterion 21 is used, but use only Symbol [or P] to indicate that 

 the toxic effect or death has been demonstrated even though the dose coded is just below the 

 threshold dose. ) 



K The response does not occur at the coded dose. (When the response is "death", refer to the 

 final statement in parentheses, below. ) 



The maximum tolerated dose level has been determined; the coded dose is known to be 

 the MTD. 



The dose administered (the coded dose) is demonstrated to be the largest that can be 

 administered, for reasons of associated toxicity, e.g. 



The compound is demonstrated to be inactive below the toxic level (or other level) that 

 prohibits administration of larger doses. 



(If "death" is coded in Field T-2 and is not caused by any doses administered, use Symbol K 

 if it seems that administration of a larger dose is impractical or even impossible. I. e. , use 

 Symbol K only if it seems to have been demonstrated that the test compound could not cause 

 "death" under conditions of the test. When Criterion 21, maximum tolerated dose, is used 

 in Field X, do not use Symbol K in Field W, for reasons explained in the definition for 

 Symbol J. ) 



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