FIELD W 

 Column 68 



Positive Response 



The following five symbols, L, M, N, 0, and P, are used only when the response coded in 

 Field T has been positively produced by the test compound. Thus, when one of these symbols is used 

 in Field W, Field X must not be coded with Criterion 01, 02, or 62 with Symbol 1 in Field Y. With the 

 latter coding in Fields X and Y, only Symbol J or K or possibly Q can be used in Field W. 



L Only one dose level has been tested (the coded dose). (When the response is "death", 

 refer to the final statements in parentheses, below. ) 



The maximum tolerated dose level has not been determined; the coded dose is not known to 

 be the MTD. 



The response intensity has not been demonstrated to be the maximum intensity of which the 

 compound is capable. 



The dose tested has not been demonstrated to be the minimum dose needed to cause the 

 response intensity produced. 



(When "death" [coded in Field T-2] is the response to the single dose level tested, Symbol L 

 can not be used in Field W, unless [1] the single test dose level has been applied to a 

 population, [2] the percent kill is less than 100% , and [3] the dose level is not, or is not 

 known to be, the largest dose practical or possible to administer; if the dose level is known 



to be the largest dose practical or possible to administer and response is less than 100% 

 kill, use Symbol M. When death is produced in the individual organism, when only a single 

 organism is treated, or in 100% of the organisms of a population treated, when only a single 

 dose level is tested [i. e. , the dose is not demonstrated to be the minimum needed], use 

 Symbol M. ) 



M Only one dose level has been tested (the coded dose), but it is known from previous tests 

 to be the maximum tolerated dose. (When the response is "death", refer to the final 

 statements in parentheses, below. ) 



Because the dose administered is the MTD, the response intensity is the maximum possible, 

 even though it is not known whether, barring its associated toxicity, the compound would 

 not produce greater response with a larger dose. 



The coded dose has not been demonstrated to be the minimal needed to cause the response 

 intensity produced in the test being coded. 



(When "death" [coded in Field T-2] is the response to the single dose level tested. Symbol M 

 is used whether or not the dose level tested is known to be the largest dose that can be ad- 

 ministered--if the death has been caused in a test using a single individual or if the death 

 occurs in 100% of a population treated. However, if application is to a population and 

 "death" [coded in Field T-2] occurs in less than 100% of the population. Symbol M is used 

 only if the test compound was applied at the dose level known to be the largest practical 

 or possible to administer; if this is not known or is known not to be the case. Symbol L must 

 be used for less-than- 100% kill. ) 



N Two or more tests have been performed, each with a different dose level. (When the response 

 is "death", refer to the final statements in parentheses, below. ) 



All those doses tested have produced the response and at the same intensity. 



Because all doses tested produce the same response intensity, the response intensity of the 

 test being coded is maximal (barring a complex dosage-response curve which rises after a 

 plateau on which the tested doses have fallen). 



The dose administered (the coded dose) is not demonstrated to be the minimum needed to 

 cause the response intensity produced. 



178 



