FIELD X 

 Columns 69 and 70 



FIELD Y 

 Column 71 



Field X 



Field Y 



Note: Criteria 10, 11, 12, and 13 are to be used when the 

 response is measured only in terms of one of the time values 

 defined below. If the data indicate the percentage of indi- 

 viduals to which a given time value applies (e.g. , "40% of 

 individuals are dead after 10 minutes"). Criterion 54 (instead 

 of 13), 57 (instead of 12), 58 (instead of 10), or 59 (instead 

 of 11) should be used and the data plotted on the Grid. If, 

 in addition to the time values, the data include information 

 about the intensity of response in the individual (e. g. , 50% 

 Increase in blood pressure or 20% decrease in urine output), 

 a code evaluation of this measure can only be accomplished 

 by constructing another code line using Criterion 62. 



10 Time to specific action other than death. 



(Killing time as a criterion is coded with 

 Symbol 1 1 as defined below. ) Speed with 

 which the test compound produces the 

 specific action. Time from beginning of 

 administration of the test compound to the 

 first appearance of the response. 



11 Killing time. Speed with which the test 



compound kills. Time from the beginning 

 of administration of the test compound to 

 the death of the organism. 



12 Alteration of survival time. The test 



compound's increase or decrease of the 

 time taken by some lethal factor (other 

 than the test compound, e. g. , a path- 

 ogen, poison, or radiation) to kill the 

 test organism. 



13 Duration of action. The length of time 



over which the test compound causes the 

 specific response in the test organism. 



Criteria 10 and 11 only: 



In the case of these two criteria, the 

 brevity of the time periods (Field U, 

 Symbols 1, 2, and 3, e. g; ) is a 

 measure of the test compound's ability 

 to cause the response. I. e. , the shorter 

 the time period, the greater is the test 

 compound's activity. 



Therefore, transfer the reciprocal of the 

 symbol coded in Field U (Column 66) to 

 Field Y. 



Criteria 12 and 13 only: 



the 



In the case of these two criteria, 

 longer the time period (Field U, 

 Symbols 9, 8, 7, e. g. ) the greater is 

 the test compound's activity indicated 

 to be. 



Therefore, transfer the symbol coded 

 in Column 66 of Field U to Field Y as 

 the measure of the compound's comparative 

 intensity of activity. 



184 



