22 IIIMAN .M.V(;.\1\ HKTlCTl-r; IX XOUMAl, AM) I'A1II()I,( HIK'AI. 1)K\ Kl.Ol'MENT. 



embryo was found I'licircli'd hy a larjro mass of traiisi)aront, tough, stringy reticular 

 magma, whicli was remo^•e(l only with groat dithculty. It behaved nmch like the 

 vitreous humor of the eye. On account of its great ciuantity we at once suspected 

 that the specimen was pathological, and after the embryo was removed it proved to 

 be so. Although ciuite advanced in development, its head was found to be smaller 

 than normal, the tissues of the face were dissociated, and the borders of the eye were 

 not sharj) but ragged. Xo doubt the specimen had continued to develop normally 

 until shortly before the operation, and the magma increased in (juantity and became 

 tough and fibrous. It is an interesting specimen, showing changes in the magma 

 late in development. Sections of the implanted ovum have not yet been made 

 The specimen is from a negress, 45 years of age, who had had 9 previous i)regnaii- 

 cies. Her last menstrual period was 67 days before the operation. Pregnancy was 

 suspected before the removal of the uterus, but a hysterectomy was performed 

 because her i)(n-io(ls had Ix-come very severe, lasting 8 days and causing faintness 

 and weakness. 



The two types of degeneration which the reticular magma undergoes have been 

 considered above. The magma becomes granular and denser as it lessens and be- 

 comes liquid. The liciuid again either coagulates or remains fluid when the speci- 

 men is fixed in formalin. The two fluid tyjics may be r(>lat(^d to the destruction of 

 the amnion, but as yet I have been unable to reach a conclusion regarding this pcjint. 



The lieginning of the formation of granular magma is shown in specimens No. 

 560 and 991 (plate 1, figures 6 and 7) as well as in Nos. 533 (plate 2, figure 3) and 

 660 (plate 3, figure 5). It appears to extend into the cavity of the amnion, and often 

 forms great crusts, which surround the embryo, as shown in several specimens 

 pictured in my monograph on monsters (e. g., Nos. 79, 94, 104, 230, and 261). An 

 extreme specimen of granular magma within the exoccelom is sho\\-n in specimen 

 No. 651<7 (plate 1, figure 9). 



It is extremely difficult to determine with certainty the structure of the granular 

 uKigma, but in studying pathological ova (especially those obtained from tubal preg- 

 nancy) I have frequently observed that there are large masses of granular magma 

 which take on hematoxylin stain. These granules are mixed with a slimy mass 

 which also takes on hematoxylin stain. ]\Iy attention was called to these granules 

 because they have a characteristic circular stratification and contain within their 

 centers small granules which also stain intensely. I am by no means certain 

 whether all granular magma stains in this way with hematoxylin, and what I have 

 just stated may apply only to a portion of the granular magma. 



Si)ecimen No. 531 (shown in figure 8, plate 1) has its coolom filled with a liciuid 

 mass m which there is a granular deposit that surrounds the eniljryo anlage. Such 

 specimens are numerous and, without opening them, they may fre([uently be recog- 

 nized by the transparency of the chorionic wall, which is covered with but few 

 atrophic villi. A more advanced embrj'o, showing the sam(> condition, is .shown 

 in specimen No. 512. In it the embryo is atrophic and macerated, without the 

 jiresence of an amnion. The chorion is thin and is fully covered with delicate degen- 

 erated villi. Other specimens which come within this group are Nos. 21, 78, 122, and 

 244a. These are all illustrated in my monograph on monsters. 



