FIELD B 

 Column 10 



(1) CONDITIONING AGENT 



(2) MISCELLANEOUS INFORMATION ABOUT THE 



TEST COMPOUND ADMINISTRATION 



(3) INDICATION THAT IN THE DATA SOURCE THERE 



IS INFORMATION ON THE EFFECT OF 

 pH ON THE CHEMICAL ACTION 



General Use 



This field is principally for recording the presence of inert materials which are administered, 

 with the test compound and its solvent or vehicle , for providing increased viscosity, facilitating 

 emulsification or spreading, etc. 



In general, when a material regarded as an inert conditioning agent is administered with the 

 test compound, it is adequate merely to code the fact of its presence, rather than attempt to assign 

 code symbols to each agent or to each type of agent. Symbol 1 is used for this purpose. 



However, symbols have been given to a number of specific materials used very frequently for 

 changing viscosity or imparting physical stability of a preparation. Note that in this field, coding of 

 agar or gelatin, for example, is not a record of any use of the materials as biological culture media 

 ingredients, but describes exclusively their use in conditioning test compound preparations . 



Field B h3S afforded space for making a coded record of certain information relevant to the 

 conditions of administration, which may affect the interpretation of the coded line (e. g. , administration 

 of mixtures or precursors). 



Finally, a symbol has been provided to permit recovery of all references with information on 

 specific effects of pH on biological responses. 



Specific Directions and Explanations 



1. Information about influence of pH on the test compound's action on the test organism 



Symbol 9 in Field B is used to indicate that the article from which the data were taken contains 

 information on the effect of pH on the effect of the test compound coded in Fields T- 1 and T-2. 



2. Use of Symbol 7; administration of the test compound as its precursor 



Symbol 7 should be used only when it has been demonstrated that the predecessor of the test 

 compound j_s converted to the test compound and does not itself affect the action coded in Fields T- 1 

 and T-2. Under the conditions when Symbol 7 can be used, a separate Code Sheet is always made for 

 the administered compound, on which Field B is not coded with Symbol 7, recording the administered 

 compound's conversion (Symbol Series FE--, Field T-2). Unless definite evidence is given by the 

 author that the administered compound is inactive (relative to the action coded in Fields T- 1 and T-2) 

 and that its conversion product is active, that conversion product can not be coded as a test compound 

 with Symbol 7 in Field B. When such evidence is lacking or even if it is well known by the coder but 

 not so described by the author, the action must be coded only as being that of the compound adminis- 

 tered (i. e. , as being the result of administering that compound). The symbol is useful mostly in 

 coding distribution studies (Symbol Series F9-- and FA--, e. g. , of Field T-2) when the compound 

 deposited and measured is shown to be a derivative of the compound administered and concentration 

 is expressed in terms of the derivative. 



Example: Penicillin is more highly concentrated in lung tissue when introduced as 

 Leocillin (from which penicillin is biologically derived by degradation) than when 

 penicillin is itself administered. To record that penicillin is deposited in greatest 



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