HELD B 

 Column 10 



amounts when administered as a given dose of Leocillin, penicillin is treated by the 

 coder as the test compound and Field B is coded with Symbol 7 to record that the 

 compound was administered as a dose of a precursor (Leocillin), coded in Fields M 

 or N. On a separate code sheet for Leocillin, the conversion of this compound to 

 penicillin is coded. 



3. Formulations 



Symbol 6 is a provision for coding the fact that the test compound is administered as an ingre- 

 dient of a formulation. A formulation is defined as a product containing a given proportion of the test 

 compound, the remaining ingredients being disregarded and presumably inert. Symbol 6 accommodates 

 only cases in which the action is attributed to a single ingredient. The coded dose of such a formu- 

 lation should be the calculated amount of the test compound. When the author specifically states that 

 he is administering mixtures of two or more compounds, any of which is being tested as an antagonist, 

 synergist, or simulant for any one of the others, none of the compounds is to be coded except by the 

 procedure described in Division 5 below. The percentage of the test compound in the formulation 

 administered or the percentage purity (which percentage values have been used in calculating the dose 

 coded in Fields M and N) should be given in the written abstract portion of Field B with the name of 

 the formulation, if given by the author. Do not place the formulation name or the per cent purity on 

 the chemistry side of the Code Sheet; place there only the test compound name. The CBCC policy has 

 been to admit few data from tests using formulations. 



4. Mixtures 



Symbol is provided to allow, when it is so desired, the coding of data from tests in which a 

 mixture of compounds is administered, the results of the test not being attributable to any one compound 

 of the mixture. In such a case, the mixture is not assigned a unique Chemical Serial Number; instead, 

 the data are recorded first on a Code Sheet for one of the compounds, with Symbol coded in Field B. 

 Unless there is reason to do otherwise, the line must be duplicated on separate Sheets for each compound 

 of the mixture. In coding test compound mixtures, the dose coded is expressed in terms of the total 

 mixture. 



In selecting chemical-biological test data, the CBCC has seldom elected to include data from 

 tests of chemical mixtures. Mixtures, as discussed here, exclude cases in which there are given 

 data for each of the mixture's compounds tested separately so that the results can be interpreted in 

 terms of synergism, antagonism, or additive effects. 



5. Symbols available for additional items of Field B 



Symbol 8 and all letter symbols, with the exception of letters F, G, I, 0, P, R, and S through Z 

 may be used for additional items of Field B. (Letters S-Z are unavailable by having used the IBM 

 zone punch as a symbol and the other six letters are unavailable because Symbols 6, 7, and 9 can be 

 double punched with any one of Symbols 1, 2, 3, 4, 5, and 9). 



6. File of coded biology data arranged according to symbols for conditioning agents 



No separate file of coded biology data on IBM punched cards, arranged by Field B entries, is 

 maintained by the CBCC. 



7. Double coding in Field B, as distinguished from coding of two types of information in 

 Field B in the same line 



The CBCC has not double-coded two or more conditioning agents used in separate test runs, 

 for the same general reasons as given for not double-coding two or more states of the test compound 

 in Field A. (See the last division of the Specific Directions and Explanations section for Field A. ) 



Note that the definitions of "formulation" and "mixture of compounds" do not include the mixture of 

 isomeric forms of a compound; the latter would be regarded chemically as a single compound for 

 coding purposes. 



- 8 



