FIELD D 

 Columns 12, 13, 14, 

 15, 16, and 17 



C. Symbol FF-G of Field T-2: When there is a test compound which has an effect 

 on the elimination of a metabolite of a compound and the metabolite is named . 

 For example: The test compound causes an increase in urinary excretion of the 

 metabolic product (Compound Y ) of Compound X , (In this example, Compounds X 

 and Y vie for a place in Field D, since Symbol FF1G [metabolite of the chemical 

 specified in Field D ] requires Compound X being in Field D and general directions 

 require that the identity of the metabolic product [Compound Y] be coded in Field 

 D when known. ) 



The parent compound is coded in Field D. In Field T-2, G is coded with 



whichever of Symbols FF1- to FFD- is appropriate (in the example above, 

 FF1G); in the written abstract portion of Field T-2, the name of the metabolite 

 is only written and is coded nowhere. 



A second line is not coded to indicate the action of the test compound on 

 the elimination of the metabolite (which would provide a line with the 

 metabolite coded in Field D), since the specification for coding the metabolite 

 in Field D is merely a matter of adding supplementary information when it is 

 known; the code name of the metabolite is not actually essential to the 

 interpretation of the coded action of the test compound. 



D. When the test compound has an effect on the nutrient uptake, chemosynthesis, 

 distribution, etc. (i.e., Field T-2, Symbols F6--, F8--, etc.), of a secondary 

 compound whose name is specified and the action is evaluated by comparison 

 with a standard. E. g. : The test compound causes an increase in absorption of 

 Vitamin C, the degree of increase being evaluated by comparison to the increase 

 caused by a standard, Compound X. (Since the vitamin is specified as Vitamin C, 

 Vitamin C should be coded in Field D; however, the standard compound should 

 also be in Field D. ) 



Two lines are to be coded, if the action is positive. 



In the first line, place in Field D the compound whose nutrient uptake, 

 chemosynthesis, distribution, etc. , is affected. Evaluate the effectiveness 

 by the Grid (percentage increase or decrease) or, if the actual control value 

 and value following treatment are not reported, evaluate by Criterion 01 of 

 Field X with an evaluation or 1 in Field Y. In any case, do not use 

 Criterion 03 or 04. 



Code the second line to be like the first line in all fields except Field D and the 

 evaluation fields; use Criterion 03 or 04 and code the standard compound in 

 Field D, adding Symbol * (representing the IBM 12 zone punch) in Column 17 . 



In summary, it will be noted that the resolution of the conflicts reflects a precedence given 

 to coding in Field D compounds whose actions have been affected by the test compound, as indicated 

 by Symbols 8, 9, A, and C in Field T-l; such secondary compounds are always coded. (See Conflicts 

 A and B. ) Second in the scale of precedence is the coding of compounds used as standards of 

 comparison to the test compound; the CBCC also always codes the standard of comparison, even when 

 a second code line is necessary to code a standard used to evaluate the effect of the test compound 

 on the action of a secondary compound, using Symbol * in Column 17 of the line coding the standard 

 compound in Field D. (See Conflicts B and D. ) Last in the list is the coding of compounds whose 

 metabolic fate is affected- -or compounds to which tolerance/sensitization is produced- -by the test 

 compound, indicated by certain symbols of Field T-2; if this last use conflicts with either of the first 

 two major uses above, the CBCC prefers omitting coding the compound called for by Field T-2 on the 

 grounds that it is of least importance. (See Conflict A. ) In view of this, retrieval of all compounds 

 whose metabolic fate is affected (as indicated by coding in Field T-2) can not be accomplished by 

 sorting in Field D for coded biology data. (The only practical way of finding these would be by 

 selecting IBM cards with the particular symbol or symbols in Field T-2 and sorting for Symbols 8, 9, 

 A, or C in Field T- 1 and for a 12 zone punch in Column 17 of Field D; if none of these symbols of 

 Fields T- 1 and D are on the cards, coding in Field D on all the IBM cards at hand is of compounds 



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