FIELD E 



Columns 18, 19, 20, 21, 



22, 23, 24, and 25 



ORGANISM, TUMOR OR PATHOLOGICAL CONDITION 

 ACTED ON BY THE TEST COMPOUND 



GENERAL DISCUSSION 



This field is for the entry of one of the following: 



I (1) TEST ORGANISM ACTED ON BY THE TEST COMPOUND 



(2) TUMOR ACTED ON BY THE TEST COMPOUND 



(3) PATHOLOGICAL CONDITION OTHER THAN TUMOR 



ACTED ON BY THE TEST COMPOUND 



II (4) TUMOR PRODUCED BY THE TEST COMPOUND 



Organization 



The Biology Code has been provided, as far as possible and to the extent of its anticipated 

 needs , with unique symbols for the species of organism used or for the precise pathology treated. 

 These symbols bear relationships to each other, based on relations between organisms or between 

 diseases so that, first, retrieval of coded data is possible at any taxonomic level or at any level of 

 pathology description and, secondly, appendage to the Code of new symbols for additional organisms 

 or pathologies is possible in a logical relation to the pre-existing code items. 



The symbols for organisms, pathologies, and tumors are assigned according to definite schemes. 

 Since each scheme is specially designed to provide symbols which reveal relationships between 

 organisms, or pathologies, or tumors, by any of their several characteristics, each can be considered 

 essentially as a separate Code. The Taxonomy Code requires, for example, that a new organism be 

 assigned a symbol whose first unit represents the phylum to which it belongs. As another example, 

 the Tumor Code rules specify that, when a symbol is assigned to a new tumor, the second and third 

 units of that symbol must represent the organ in which the tumor originated. Every organism, every 

 tumor, and every pathology is coded according to the rules of that particular Code. However, once it 

 is coded, it is added to the list of organisms, pathologies, or tumors so that it need never be coded 

 again. These Field E lists, then, are actually groups of pre-coded items, any one of which will never 

 vary in the coding of its identity. The lists of organisms, pathologies, and tumors are included in the 

 CBCC Biology Code as the Taxonomy, Pathology, and Tumor Codes of Field E. 



Following this general discussion of Field E is a separate discussion for each of the Taxonomy, 

 Tumor, and Pathology Codes, explaining how the symbols are formed for organisms, tumors, and 

 pathologies and what coded information about an organism, tumor, or pathology is incorporated into 

 its symbols. 



General Use 



In Field E is coded the major biological component of the test data, the organism, the pathological 

 condition, or tumor which is experimentally treated with the test compound. A pathological condition 

 produced by the test compound (excepting tumors) is always identified specifically in Field T-2. 



When a compound is tested for its ability to induce tumors , the effect tested for is coded in 

 Field T (Field T-l, Symbol 7; Field T-2, Symbol 43: "induces neoplasm"). However, to provide for 

 coded identification of any tumor actually induced, the tumor identity is coded in Field E and the 

 organism in which it is induced is placed in Field J. Only in the case of tumor induction (Symbol 43 of 

 Field T-2) is Field E used to code the identity of the result of the test compound's action. In all other 

 cases, as explained above, an entry in Field E represents the organism, pathology, or tumor treated by 

 the test compound. 



It is important also that distinction between the uses and structures of symbols of Fields E and 

 J be understood. Experience has proved that frequently the points of difference are not always 



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