FIELD E 

 Columns 18, 19, 20, 21, 

 22, 23, 24, and 25 



IBM punched cards with the symbol for the housefly otherwise undistinguished , but there must be 

 included a search for cards with symbols of any and all housefly strains . Only by weighing the disad- 

 vantage of this additional complication in retrieval against the advantage of having the particular 

 strain distinguished in Field E, has the CBCC made the decisions, which were special in each case, 

 to permit certain strain distinctions by unique Field E taxonomy symbols. 



6. Test organism versus host; distinctions 



It is important that the coder understand the definition of a host organism, for which Field J 

 is provided. In any experimental situation in which one organism is living as a parasite on another 

 organism, there are three considerations to make, which will determine what will be coded in Field E: 



(A) Was the compound being tested for, or did it produce, an action on the parasite and 



thereby affect the host? If so, the parasite should be coded in Field E and the host 

 in Field J. (E. g. , to code that the test compound causes some relief from malaria in 

 chicks, the malarial organism is coded in Field E, the chick in Field J. ) 



(B) Was the compound being tested for, or did it produce, an action directly on the host , 

 irrelevant to the parasite? If so, and that action is being coded, the host of this 

 situation is actually the test organism to be coded in Field E and the infestation is 

 merely an incidental condition which is indicated by coding Field G with Symbol 5. 

 (E. g. , to code that the test compound causes increased heart rate and 50% mortality 



in chicks with intestinal roundworms [or body lice or coccidia, e. g. ] when the parasites 

 in controls cause neither an altered heart rate nor death, the chicken is coded in Field 

 E and Symbol 5 in Field G-l. ) 



(C) Was the test compound being tested for, or did it produce, an effect on some single 

 symptom of the pathological condition of the host caused by the test organism, when 

 the condition as a whole was not significantly affected? (This is a difficult coding 

 problem; it is discussed later in this Section, in Part IV, Division 5. ) The host of this 

 particular situation is coded in Field J and the test organism (whose symbol in the 

 Taxonomy Code is given synonomy, in the CBCC Pathology Code, with the pathology 

 syndrome it causes) is coded in Field E; the action on the symptom is coded by the 

 appropriate code symbols in Field T. 



7. General directions 



When coding of Field E is completed and this coding is not of a species but only of a genus 

 or family so that one or more of the final code boxes in the field are left uncoded, those uncoded boxes 

 are to be cross-hatched. 



In the language portion, the complete scientific name of the organism is written and under- 

 lined. If the common name is given, it is also included, being written after the scientific name and 

 not underlined. 



II. TUMORS AGAINST WHICH COMPOUNDS ARE TESTED; TUMORS PRODUCED BY COMPOUNDS 

 (Tumor Code) 



1. Tumor against which a compound is tested 



Any tumor, whether induced, transplanted, or spontaneous, that is treated with a test 

 compound is coded in Field E by a symbol found in the Tumor Code of Field E. The animal, plant, or 

 medium which harbors the tumor at the time of the test is coded in Field J as the host, whether or not 

 that host is the parent source of the tumor. The parent source of the tumor, if different from the host 

 in Field J and if not clearly implied by the tumor identity in Field E, can not be recorded by code, 

 because providing a special coding field for this occurrence is impractical for the CBCC Code; however, 

 this different parent source, under these conditions, must be recorded in the written abstract of Field E. 

 For example, in coding data from a test with a mouse tumor transplanted to a culture medium, the 

 medium would be coded in Field J, but the mouse origin can only be recorded in the written abstract. 



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