F IELD E 

 Columns 18, 19, 20, 21, 

 22, 23, 24, and 25 



If the location of the tumor is described as one specific organ of the host coded in Field J 

 (i. e. , any one specific item of Field H-l), that organ should be coded in Field H-l. This procedure 

 satisfies the purpose of Field H-l which is to record the responding organ. 



If the tumor is a transplanted tumor, the one specific organ to which it is transplanted is 

 coded in Field H-l, whether the organ of origin was of the host coded in Field J or of another organism. 

 The CBCC Code considers the organ that is host to the transplanted tumor as being the diseased organ 

 rather than the organ whose cells have altered to the tumorous state. Thus, if the organ of origin is 

 different from the organ to which it is transplanted, the organ of origin is only recorded as part of the 

 code symbol for the tumor. Whether the organ of origin is or is not indicated specifically by the tumor 

 symbol in Field E, it should be included in the written abstract of Field E. Notice that there are being 

 discussed here only transplanted tumors. For action on metastasizing of tumors, see Division 5 of the 

 Specific Directions and Explanations of Field H-l and the Code definition for Symbol 46 of Field T-2. 



If the same tumor is described as being in more than a single organ (more than one specific 

 item of Field H-l), it is ordinarily adequate to code only a single line with one of the organs coded in 

 Field H-l. However, if the tumor response differs according to its anatomical location, as many code 

 lines should be constructed as there are tumor locations that respond differently to a degree that can 

 be distinguished by code in Field Y. 



In the case of tumors being treated which are known to have been chemically induced, the 

 fact that they were so induced is indicated by Symbol T ("chemically induced") in Field F; if the 

 identity of that carcinogen is known, it may be included in the written abstract, but it is not considered 

 a significant component of the data being coded and is not coded in Field D. 



2. Tumors produced by compounds 



Any tumor produced by a test compound is coded in Field E by symbols found in the Tumor 

 Code of Field E. The organism in which the tumor is produced is coded in Field J, since it is the host 

 of the tumor at the same time that it is the origin of the tumor. 



If the location of the produced tumor is described as being in one specific organ , that organ 

 should be coded in Field H-l; if the same tumor is produced in more than one organ, ordinarily only a 

 single line is necessary, with one of the organs coded in Field H-l. 



If a compound is tested as a carcinogen, yet no tumor is produced, Field E is coded merely 

 with the Symbol S ("tumor, unspecified") in Column 18 and the organism treated with the candidate 

 carcinogen is coded in Field J. This permits retrieving from the file all data on tumors, including 

 negative carcinogenic data, by reference to a single field, Field E. 



3. Coding distinction between tumors treated and tumors produced by the test compound 



Although there is not a coded distinction, in Field E, between tumors which test compounds 

 affect and tumors which test compounds produce, the coder will recognize that the two are distinguished 

 by the coding in Fields T-2 and T-3. 



4. Pretreatment of the host of a tumor 



Any pretreatment given to the host or part of the host (including the anatomical site of a 

 spontaneous or transplanted tumor), which results in a special experimental state of that host or 

 structure, is coded only in Field L. 



III. SOURCES OF ENZYMES ACTED UPON BY TEST COMPOUNDS 



Enzymes are never coded in Field E; they are always coded in Field T-2. (See the Enzyme Code 

 of Field T-2 and Division 22 of the Specific Directions and Explanations for Field T-2. ) The animal or 

 plant source of the enzyme is coded in Field E (Taxonomy Code) and, if the organ from which the enzyme 

 is derived is known, that organ is coded in Field H-l. Frequently, in enzyme studies, Field G is coded 

 with one of the Symbols U through X, to indicate the test preparation. (See the Code for definitions of 

 Symbols U through X which will explain their use in this situation. ) 



22 - 



