FIELD E 

 Columns 18, 19, 20, 21, 

 22, 23, 24, and 25 



In the case of enzymes described as purified, crystalline, recrystallized, etc. , especially 

 commercially available enzymes so designated, and undesignated as to biological source, code the 

 source in Field E with Symbol Z, Zl, or Z2 and record all information given (commercial source, number 

 of crystallizations, assay, chemical properties of the lot, etc. ). 



IV. PATHOLOGY TREATED BY THE TEST COMPOUND ( Pathology Code ) 



1. Pathology treated vs. pathology produced; distinction in coding procedure 



Only a pathological state that is treated by the test compound is coded in Field E, using 

 symbols found in the Pathology Code of Field E. (The discussion of the Pathology Code will explain 

 that a specific pathology is actually frequently represented by a basic pathology symbol in Field E 

 combined with a specific code entry in Field H. ) The production of a pathological state by a test 

 compound is coded in Fields T-l, T-2, and T-3. (Consult Part V below for this latter situation. ) 



2. Host of the treated pathology 



The organism that is in the treated pathological state is coded in Field J as the host of the 

 pathology. (The pathological state is essentially coded in Fields E and H. ) 



3. Coexisting pathological conditions; only one is treated 



If a complex of apparently unrelated pathological conditions exists in an organism and the 

 test compound is administered to treat only one, the treated condition is coded in Field E and Field L 

 is coded with Symbol 7 (or other appropriate symbol) to indicate that there are coexisting pathological 

 conditions. (E. g. , the test compound is administered to treat experimental hypertension in dogs which 

 are incidentally anaemic and infected with mange. ) 



4. Coexisting pathological conditions; any or all treated 



If a complex of apparently unrelated pathological conditions exists in an organism and the 

 test compound is administered, with no clue as to which condition it was particularly intended to treat 

 or with no intention of treating one more than the other, the policy is to code a line for each pathological 

 state, recording either the negative or positive responses of each and indicating in each line (Field L) 

 that coexisting pathological conditions exist. (E. g. , the test compound is administered to a dog with 

 pulmonary edema, conjunctivitis, and tapeworms; no improvement in any of the three conditions is 

 observed. ) 



5. One pathological condition, several related conditions as symptoms 



(See also Part I, Division 6, Subdivision [C]. ) When the situation involves a complex of 

 related conditions (i. e. , symptoms of a major pathology), the coding procedure must be based on the 

 premise that it is desirable always to have coded in Fields E and H the major pathology , any or all of 

 whose symptoms may be affected by the test compound. Therefore: 



(A) When a test compound is administered to an organism with a specified pathological 

 condition and only one of the symptoms of that condition responds but there is no 

 evidence that any of the remaining symptoms respond, the specified major pathological 

 condition is coded in Field E and the symptom that responded and its response are coded 

 by appropriate symbols in Fields T-l and T-2. If more than one, but not all such 

 symptoms should respond, each symptom's response must be on a separate line in 

 Field T-2. The symptoms which did not respond to the treatment should not be coded 

 on separate lines. 



In this particular situation, the CBCC policy has been to use discretion so that usually only one or 

 two of a group of affected symptoms are actually selected for coding. 



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