FIELD F 

 Column 26 



If the author specifies that, in a group of test organisms used in a single test, both sexes are 

 used, there is an implication that the choice of both sexes has some significance. Therefore, this 

 fact is coded by entering both of Symbols * and # in Column 26. (See also Division 4 below, describing 

 double coding, which differs from the use of both Symbols * and § as just described. ) 



3. Stage of development to be coded in Field F 



When the lapse of time between application of the test compound and the observation of response 

 is of such duration that the test organism progresses from one developmental stage to another, the 

 question arises as to whether there should be coded the stage given the test compound or the stage in 

 which the response is manifest, since there is only one field (Field F) provided for this category of 

 information. The CBCC has defined its single Field F to limit it to coding the stage at which the test 

 compound was administered, which makes for consistency in the code statement describing the adminis- 

 tration of the test compound- -the dose recorded in Fields M and N, in the conditions recorded in Fields 

 A, B, and C, by the route indicated by Field S-3, to the stage of the organism coded in Field F. 



Unfortunately, the stage on which the observation is made (if later than the stage to which the 

 compound is administered) can not be coded, because the CBCC has not felt that the few occasions when 

 a second Field F would be needed for this justified reserving IBM space for it. The stage responding 

 must be described in the written abstract portion of the field. The action coded in Field T and the 

 evaluation time coded in Field V may sometimes suggest that the responding stage is a later stage than 

 the one treated (Field F). 



When Symbol is coded in Field S-3, indicating that the test compound was applied to the 

 parent, with the response (coded in Field T) observed on the offspring, the stage of development of the 

 offspring at the time of application of the test compound, if known, is coded in Field F. (This is par- 

 ticularly in reference to viviparous organisms in which the developing young organism is exposed, just 

 as an organ would be, to the test compound. ) If the stage of development at the time of administration 

 of the compound is not specified by the author, nothing will be coded in Field F, because Symbol of 

 Field S-3 describes the situation adequately. 



4. Double coding of results from two or more tests with the only variable being sex or stage 

 of development 



If separate sexes are used in separate test runs and the only difference in the procedure is the 

 sex of the organism and if the results of the tests are so similar that they can not be distinguished by 

 the Code, a single code line is adequate for both tests, with Field F coded with Symbols * and #. (This 

 combination of two or more tests in a single line, accomplished by a double entry in one field, is re- 

 ferred to as double coding. ) The written abstract of Field F should record clearly the fact that the code 

 line represents separate tests using different sexes rather than a single test using both sexes . The 

 latter is described in Division 2. 



If tests are made at each of several stages of development (the stages of development being 

 the only variable in the tests) and the response and evaluation for all these tests are so nearly the 

 same that they can not be distinguished by the Code, double coding with any of Symbols 1 through 9 

 is permitted. This double coding of stages does not interfere with double entry for both sexes in the 

 same line. (See the last paragraph of Division 2. ) 



5. Use of Field F to record tumor information 



When Field E has no test organism or infectious pathology coded in it (but is coded with a 

 non- infectious pathology or tumor being treated ), there is no need for a field to code sex or stage of 

 development of the entry in Field E. Therefore, under those circumstances, Field F is free for 

 describing another Field E entry, a treated tumor, and Symbols S through Z have been assigned for 

 coding this information. (Since, under the circumstances when Symbols S through Z can be used, 

 Field F would not be used for coding sex and stage of development of an organism, Symbols 1 through 8 

 might have been given second meanings- -these tumor descriptions- -so that when an organism was 

 coded in Field E, Symbol 1, for example, would represent a stage of development, but when a tumor 

 was coded in Field E, Symbol 1 would represent a characteristic of that tumor. To make interpretation 

 of one field [in this case, Field F] dependent on the entry of another field [Field E] when it can be 

 avoided, is impractical and it was for this reason that Symbols S through Z were chosen rather than 



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