FIELD G 

 ( Field G-l) (Field G-Z) 

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PRETREATMENT OR 



EXPERIMENTAL STATE OF THE 



TEST ORGANISM OR OF THE ORGAN, 



TISSUE, OR CELL OF THE TEST ORGANISM 



Symbol Z only: 



EXPERIMENTAL TREATMENT OF THE TEST 



ORGANISM OTHER THAN TREATMENT 



WITH THE TEST COMPOUND AND 



COMPOUND CODED IN FIELD D 



General Use 



1. Field G (Fields G-l and G-2, considered collectively) 



Field G is used to code any state or condition of the test organism, preparatory for or 

 coincidental with the experiment with the test compound. Such a state may be the result of appropriate 

 chemical or surgical pretreatment , it may be a naturally occurring special state selected for the experi- 

 ment, or it may be a condition which the test organism has by coincidence . The field is never used to 

 code a condition which is specifically treated by the test compound; such a condition is always coded 

 in Field E, not in Field G. 



In the following paragraphs discussing Field G, the expression "experimental state" is used in 

 reference to those states or conditions (of the test organism or of the organ or tissue of the test organism) 

 which are not being tested for a specific response to the test compound. Neither do these experimental 

 states bring - about a state or condition (i. e. , a pathology) which is tested for response to the test 

 compound. 



The experimental states coded in Field G include results of operative procedures that are merely 

 to facilitate the test or the observations of the responses. For example, an organ of the test organism 

 may be denervated to isolate the organ functionally from nervous control. This denervation, as an 

 operative procedure, is not a condition being specifically treated, for it is scarcely conceivable that 

 the test compound could alter that specific fact of the nerve's being severed. The purpose of such an 

 operation is to provide an organ whose response to the test compound will be exclusively chemical 

 response and not complicated by nervous responses. In this case, denervation is coded in Field G 

 (Symbol Q), the test organism to which the test organ belonged is coded in Field E, and the organ 

 isolated is coded in Field H-l. 



Included also among these experimental states are those indicating (1) that the test organism is 

 of a selected type (e. g. , a resistant strain or a sensitive strain), though the peculiarity of that type is 

 not a condition being specifically treated, or (2) that the individual organism used deviates in some 

 degree from normality (e. g. , it has a nutrient or hormone deficiency, or it happens incidentally to have 

 an infection, or it has been exposed to radiation, etc. ), though this deviation is not a condition being 

 specifically treated. 



It is urged that the definitions of the field be studied, keeping in mind their use, since frequent 

 coding errors occur due to misuse of the field, particularly in the case of beginning coders. A typical 

 error occurs in coding a test compound's effect on a given hormone deficiency; an inexperienced coder 



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