FIELDS G-l and G-2 

 Columns 27 and 28 



might code this specifically affected condition in Field G and the organism in Field E, whereas the 

 condition should be coded in Field E (since it was specifically affected) and the organism should be 

 coded in Field J as the host of the condition. On the other hand, if the test compound caused an effect 

 (e. g. , death or paralysis) on an organism which was reported to have a hormone deficiency, the coder 

 might erroneously code the deficiency in Field E, whereas the effect was actually not on the hormone 

 deficiency but on the test organism which should be coded in Field E, with the hormone deficiency 

 coded in Field G. 



Field G is restricted to expressing an experimental state or condition of the test organism in 

 Field E (or of the test organism's organ or tissue in Field H-l or I). It is not used to describe the host 

 organism coded in Field J, since a separate field (Field L) is used for this purpose, nor does it apply to 

 pathologies coded in Field E , except that Symbols F, G, H, I, and J (and possibly 6 and 8) may be used 

 to distinguish infective diseases (i. e. , to distinguish physiological strains of pathogenic test organ- 

 isms). In the case of tumors coded in Field E, certain items of Field G might conceivably be applicable, 

 if the tumor itself exhibited the experimental condition; if the experimental state is of the host of the 

 tumor (coded in Field J), that condition must never be coded in Field G, but only in Field L. 



In addition to the major purpose of Field G which the preceding paragraphs discuss, one symbol 

 of the field, Symbol Z, has been provided for and restricted to another purpose. If the experimental 

 factors (states) of Field G have been successfully defined, it will be understood that none of them is 

 considered as part of the treatment of the test organism (in the way the test compound is the treatment), 

 even though they may influence the outcome of the test. Symbol Z, however, is used to indicate a 

 treatment of the test organism other than treatment with the test compound and secondary compounds and 

 accompanying the treatment with the test compound. This single Field G symbol does not permit speci- 

 fying the treatment (i. e. , whether it was radiation, thermal, shock, etc. ) so that if Symbol Z is used, 

 the treatment must be specified in the written abstract of Field G-2. (Symbol Z is coded only in Field 

 G-2 for sake of consistency. ) 



2. Fields G-l and G-2, considered as separate fields 



In order to record the presence of more than a single experimental state (a situation that frequently 

 occurs), there are provided two places, both having the general Field G coding use, as described above. 

 These are referred to as Field G-l and Field G-2. If only one experimental state exists, it is coded in 

 Field G-l. If a second state exists, it is coded in Field G-2. Field G-2, therefore, has no special use 

 other than serving as a place to code a second condition when necessary. Since no space is available 

 for coding more than two experimental states, a third can only be entered in the written abstract portion 

 of the fields. 



If a non-chemical treatment is given with the chemical treatment, Symbol Z is used in Field G-2, 

 leaving only Field G-l for coding states of the test organism. 



3. Relationship of Field G to Fields E, H-l, H-2 and I 



While it would be more simple, in terms of interrelations, to have separate fields for describing 

 states of the test organism, states of the responding organ, states of organs other than the responding 

 organ, and states of the responding tissues, several reasons make impractical having more than a single 

 area (Fields G-l and G-2) for coding these states. Therefore, coding in Field G can not specify whether 

 it was the organism as a whole, or the organ in Field H-l, or the tissue in Field I (if all three fields 

 have entries) that was given the pretreatment or that was in the state indicated by the Field G symbol, 

 unless the symbol specifies by its definition that it was the organism, organ, or tissue. This is dis- 

 cussed again in Division 4 of the section on Specific Directions and Explanations below. 



Field H-2 is used to supplement the coding of Field G in describing certain pretreatments or 

 states (Symbols 0, P, B, S, and T) of entries in Fields E, H-l and I. 



4. Significance of information about experimental states coded in Field G 



In most cases, responses to the test compound depend upon, or are modified by, the experi- 

 mental state so that if that state were not present, the response would be to some degree different or 

 might even not occur. Therefore, it is frequently of importance and is sometimes of such importance 



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