FIELDS H-l and H-2 



Columns 29, 30, 31, 



32, 33, and 34 



with a non-living host (symbols beginning with any of letters S through Z--i. e. , with the zone punch 

 in Column 37), all coding in Fields H-l, H-2, and I designates structures of the test organism in 

 Field E. 



5. Relationship between the coding of anatomy (Fields H-l, H-2, and I) and the anatomical 

 designations of TUMOR symbols (Field E) 



Since the anatomy fields (H-l, H-2, and I) are used basically to record the anatomical site of 

 action of the test compound, they are used for coding the anatomical site of any tumor that is treated 

 in testing for carcinostatic or carcinogenic action. Although the tumor symbol bears a code designation 

 of the anatomical site of origin (when the organ origin is known), this site of origin is not always the 

 site of the tumor's location when chemically treated. Most frequently, the common experimental 

 animal tumors used for testing candidate carcinostatic drugs are transplantable and, for technical 

 convenience, such a tumor is ordinarily implanted in an organ and tissue other than the organ or tissue 

 in which it originated. Thus, organs and tissues of tumor origin (Field E) and organs and tissues of 

 locations of tumors when treated (Fields H and I) can both be indicated by code. In order to permit 

 efficient sorting in Field H, the anatomical site of a tumor is always coded in Field H-l when known, 

 even when it duplicates the anatomical coding in Field E, as in the case of treatment of spontaneous 

 tumors or tumors transplanted to other animals but at the same site as the tumor's origin. In retrieving 

 information on all tumors having a specific anatomical origin , regardless of their location when treated, 

 Field E must be searched. In retrieving information on all tumors in any given location, regardless of 

 their origins, Field H-l must be searched. 



As can be seen by reference to the description of the Tumor Code, the symbols for organs and 

 tissues incorporated into tumor symbols for Field E are not symbols of Fields H and I, but are derived 

 from a special list of structures for the Tumor Code. 



The site of an induced tumor is always coded in Fields H-l and I when this information is 

 known. 



When a compound is tested specifically for its effect on metastasis of a tumor (Symbol 46 of 

 Field T-2), the data frequently indicate all the organs to which metastasis has extended. When 

 Symbol 46 is coded in Field T-2, only one code line is prepared with the organ of origin coded in 

 Field H-l. However, if the effect of a test compound is on a tumor which has metastasized from 

 another site and the effect is not specifically on the process of metastasis (i. e. , when Field T-2 is 

 not coded with Symbol 46), Field H- 1 is coded with the site of the affected tumor (not the organ of 

 origin) and Field F is coded with Symbol Y. 



6. Relationship between the coding of anatomy (Fields H-l, H-2, and I) and the anatomical 

 designation of PATHOLOGY symbols (Field E) 



Fields H and I are always used to indicate the site of action of the test compound. Therefore, 

 when a pathological condition is coded in Field E, Fields H and I are used to code the structures 

 specifically affected by the experimental chemical treatment, regardless of whether the pathology 

 (l) may be located exclusively in that structure, (2) is located (in addition to being a pathology of 

 the responding structure) in several organs, a whole system, or the entire organism, or (3) is located 

 in another part and affects only secondarily the structure responding to the chemical treatment. 



In the case of an infectious disease, the infecting organism is always coded in Field E, the 

 host is coded in Field J, and the system, organ, or tissue, in which is located the infecting organism , 

 is coded in Fields H and I. Similarly, a non- infectious disease is indicated by a special symbol coded 

 in Field E and the system, organ, or tissue in which is located the condition responding to the chemical 

 treatment is coded in Fields H and I. 



Non-infectious pathological conditions (e. g. , coronary sclerosis), recognized and named as 

 specific diseases, are frequently restricted by their definitions to particular anatomical systems, 

 organs, or tissues. When this is the case, the Field E symbol for the pathology includes a designation 



of that anatomical structure involved (e.g., T32DP200 indicates, by -32D that the disease is 



specifically of the coronary artery). This permits Field H to be used for "modifying" the coding of 

 the system or organ indicated in the pathology symbol- -i. e. , to specify a structure of that part indi- 

 cated in the pathology symbol, or the more gross system or organ of which the structure indicated in 



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