FIELD S H-l and H-Z 



Columns 29, 30, 3 1, 



32, 33, and 34 



the pathology symbol is a part. (If the myocardium, or some other part of the heart, is affected by the 

 test compound when treatment is given for arteriosclerosis or if some particular part of the vascular 

 wall is affected, those responding parts may be indicated in Field H. ) 



Description of a given pathology condition is often very complex and the coding is necessarily 

 difficult. As a result, the retrieval of information is not as simple as in the case of information on 

 tumors or test organisms. To retrieve information on all diseases of a given anatomical structure, for 

 example, not only must the anatomy Field H-l be searched, but Field E should be searched for pathology 

 symbols with anatomical components designating the particular structure. 



Occasionally, the situation arises in which a test compound may have an effect on a disturbed 

 organ which is itself not in the precise pathological state coded in Field E, although the organ exhibits 

 pathology symptoms invariably associated with the condition coded in Field E. (An actual example 

 encountered and coded was the experimental production of frostbite in a hamster leg which, when 

 untreated, invariably caused a retarding of blood flow, as observed in peripheral vessels of the lining 

 of the cheek pouch. Application of test compounds was specifically for treatment of the retarded blood 

 flow [due to frostbite] observed in the cheek pouch. ) In coding such data, that organ in which the test 

 compound has its effect and on which test observations are made is coded in Field H-l and the organ 

 which is in the pathological state indicated in Field E is coded in Field H-2. To indicate that the organ 

 in the pathological state coded in Field E is coded in Field H-2 rather than Field H-l, an asterisk 

 (representing the IBM 12 zone punch) is coded in Column 30 of Field H-l. (Thus, for the example given 

 above, "frostbite", Symbol TB003100, would be coded in Field E, "leg" [which would ordinarily be coded 

 in Field H-l as the location of the frostbite] would be coded in Field H-2, with an asterisk in Column 30, 

 and "parietal blood vessel" would be in Field H-l as the structure responding to the test compound. ) 

 In coding the situation just described, if the specific site of administration of the test compound is at 

 neither the organ with the specific pathology of Field E (in Field H-2) nor the organ responding to 

 chemical treatment (in Field H-l), and it is not adequately indicated by the entry in Field S-3, code 

 the two organs as directed; the site of administration will not be coded except in Field S-3 where the 

 site of administration should be written in if it is not explicit by the coding of that field. 



A diagram illustrating the relationships between Field H and the pathology symbols and a 

 further discussion of these is to be found in the Field E section describing the Pathology Code. 



7. Relationship between the anatomy coding (Fields H-l, H-2, and I) and the dosage fields 

 (Fields M and N ) 



The relationships between the dosage fields and the anatomical structures coded in Fields H-l, 

 H-2, and I are thoroughly discussed in Division 5 of the Specific Directions and Explanations section 

 of Fields M and N and reference should be made to that section and division. 



8. Procedure for coding data from tests using special anatomical preparations consisting 

 of an end organ and attached nerve (e. g. , muscle- nerve preparations) 



A common experimental procedure involves the use of an effector end organ and the nerve 

 supplying the organ, the two organs being intact relative to each other, though they may be isolated 

 from the animal or in situ . Under normal conditions, a stimulus applied to the nerve leads to a 

 measurable response of the effector organ. Of these, the more common examples are nerve-muscle 

 preparations, though data from nerve-gland preparations may occur. 



Use of such an experimental preparation may vary in its objective: (1) By appropriate technique, 

 there may be demonstrated the transmission of impulse to the effector organ (muscle or gland) and 

 subsequently the effect of test compounds on this neuro- effector organ impulse transmission; (2) on 

 the other hand, the action of a test compound applied to the nerve-organ preparation may be expressed 

 only as affecting in one direction or the other the normal response of the effector organ to stimulation 

 by the nerve with no exact determination as to whether the chemical effect is on the nerve, on the 

 effector organ, or on the neuro- effector transmission. 



If the test results are demonstrated by the author actually to be in terms of effects on trans- 

 mission of the impulse (see Number 1 of the previous paragraph), the coding should record this by 

 using the appropriate impulse transmission term in Field T-2 (e. g. , neuro-muscular transmission, 

 Symbol 98). Field H-l should be coded with Symbol 17 or, if the specific nerve-organ pair are 



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