FIELDS M and N 



Columns 45 and 46; 



47 and 48 



total formulation. If the amount of the test compound (the active ingredient of the formulation) can not 

 be determined, Fields M and N should not be coded. 



If it should be desirable to code data from tests using formulations in which the active ingre- 

 dients are not specified, so that the "test compound" is only a proprietary formulation name, the 

 procedure would have to be different: The formulation name would be coded as the "test compound", 

 Field B would not be coded with Symbol 6 (since, in this case, the test compound is the formulation 

 and is not a part of a formulation), and Fields M and N would be coded with the dosage based on the 

 total formulation. 



The CBCC has coded data from tests using mixtures (i. e. , two or more test compounds known 

 to be active and administered together or two or more test compounds, all candidate for the activity 

 and administered together), but with considerable reserve. When it has seemed appropriate to include 

 such test data, Field B is coded with Symbol (to indicate that the compound coded as being the test 

 compound is actually only one of two or more compounds of a mixture and that the dosage in Fields M 

 and N and the evaluation are based on the total mixture) and Fields M and N are coded with the amount 

 of the total mixture administered. Subsequently, additional code sheets (and IBM cards) are made for 

 each of the other compounds, recording the same biology test data. 



13. Relation between Field N and Fields O and P 



Frequent coding errors justify talcing the precaution of examining carefully the coding in Fields 

 N, O, and P. The quantity coded in Field N should never be more than the quantity administered within 

 the time interval coded in Field O. The total dose given over the period of the test is the product of 

 the dose in Field N multiplied by the frequency in Field O multiplied by the duration in Field P. 



14. Coding of ad libitum feeding in Fields M, N, O, P, and S 



In coding information on ad libitum feeding, record and code in Field M the concentration of 

 the test compound in the food. The fact that the test compound is consumed ad libitum is indicated in 

 Field O by Symbol 2 and in Field S-3 by Symbol 4; the duration of the consumption of the test compound 

 (i. e. , the time from presentation of the food- test compound mixture and its withdrawal from the animal) 

 is coded in Field P. However, if after a period of ad libitum administration, the daily or weekly intake 

 of the test compound is determined or can be calculated, that daily or weekly intake is coded in Fields 

 M and N, the appropriate time interval (one day or one week, etc. ) is coded in Field O, the total 

 duration is coded in Field P, and Field S-3 is coded with Symbol 2. 



15. Relations between Fields M and N and Field Y; double coding in Fields M and N 



The ultimate concern of the discussion of this Division is with the collective data from two or 

 more consecutive tests in each of which a different dosage level of the test compound has been admin- 

 istered in an effort to discover an active level (or a tolerated level) or the most effective level (or the 

 highest tolerated level). (Division 11 discusses coding of data from tests in which more than one 

 level of the test compound were administered as a series in the same test. ) Before describing the 

 procedure for coding the collective data from such a series of tests, the characteristics of the two 

 fields, the dosage field (i. e. , Fields M and N) and the evaluation field (Field Y), and the relationships 

 between them will be briefly reviewed. 



As mentioned in the section discussing organization of Fields M and N, quantitative values 

 are reduced to code by dividing them into ranges, each range being assigned a code symbol. This is 

 not exclusively true for Fields M and N. Other fields dealing with quantitative values must be simi- 

 larly organized into code symbols, notably Fields P, Q, U, V, and Y. Any single code symbol repre- 

 senting a quantitative value is therefore only as precise as the narrowness of the range it represents 

 allows. I. e. , a symbol in Field N representing 50 to 60 mgs would code 55 mgs more precisely than 

 would a symbol representing 1-100 mgs. In Field Y, a symbol representing evaluation of a 2-3 hours 

 killing time would code more precisely the evaluation of a 2- hour killing time than a symbol represent- 

 ing evaluation of a 1-5 hours killing time. It will be helpful if in the following discussion this fact 

 is kept in mind- -that each symbol in Fields M, N, and Y represents not a single value, but a range 

 of quantitative values. 



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