FIELD R 

 Column 53 



TIME OF TREATMENT 

 RELATIVE TO: 



(1) INOCULATION 



(2) TUMOR IMPLANTATION 



(3) SENSITIZATION 



(4) INCITATION OF NON- 



INFECTIOUS PATHOLOGY 



Organization 



As with all fields of the CBCC Biology Code concerned with quantitative data, each symbol of 

 Field R designates a time range . As the symbols are listed in the Code, four groups can be recognized, 

 according to the sequence of the administration of the test compound and the infection, implantation, 

 etc. : 



1. Test compound and infection, etc., administered at the same time - -or essentially at the 

 same time (within an hour of each other). (Symbol 1) 



2. Test compound administered after the infection, etc. (Symbols 2 through B) 



3. Test compound administered before the infection, etc. (Symbols C through L) 



4. Test compound administered before and after the infection, etc. (Symbol M) 



General Use 



The time between implantation, inoculation, sensitization to the test compound, infection, 

 etc. , and the administration of the test compound is indicated in this field, when the time is relevant 

 and important to the test. 



Time values coded in Field R are those between administration of the test compound and: 



1. Implantation of a tumor (coded in Field E). 



2. Inoculation of a host with the cells or individuals of an infective stage of a pathogenic 

 test organism coded in Field E. 



3. A subsequent dose of the same compound administered to determine sensitization by the 

 primary dose. Thus, Field R may be used to code time between the administration of an 

 initial dose given experimentally as a sensitizing dose (or as a dose which reduces tolerance) 

 and the subsequent dose, when coding the sensitive response to the second dose (i. e. , when 

 not coding sensitization or tolerance reduction [Symbol 58 or a symbol of the 51-- series], 

 but indicating with Symbol 6 in Field G that the organism has been pretreated to account for 

 the sensitivity resulting in the response coded in Field T at the dose administered). See the 

 section on Specific Directions and Explanations for Field G, Division 11, Subdivision A, 



Part (1). 



4. The inciting of a specific non- infectious pathological state (coded in Field E) to be treated 

 with the test compound. (This inciting of a non- infectious pathology is never coded in 

 Field G in which could be coded, in this situation, only pretreatments or conditions other 

 than the pathology to be experimentally treated. ) 



Field R is not used to indicate the time interval between administration of the test compound 

 and the secondary compound; that information is coded in Field P. 



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