FIELD R 

 Column 53 



Specific Directions and Explanations 



1. Time to be coded when the test compound is administered PRIOR to a SINGLE implant 



If the administration of the test compound is by multiple application and the total treatment 

 with the test compound is prior to implantation, inoculation, etc. , the time interval coded in Field R 

 is the period between the last administration of the test compound and the implantation. 



If the administration of the test compound is by single application and the treatment with the 

 test compound is prior to implantation, inoculation, etc. , the time interval coded in Field R is the 

 period between the application of the test compound and the implantation. If the test compound is 

 administered continuously for a period prior to implantation, the interval coded in Field R is the period 

 between the end of the administration of the test compound and the implantation. (If the test compound 

 is administered continuously up to the time of implantation, Field R must be coded with Symbol 1. ) 



2. Time to be coded when the test compound is administered AFTER a SINGLE implant 



If the administration of the test compound is by multiple application and the treatment with 

 the test compound occurs after implantation, inoculation, etc. , the time interval coded in Field R is 

 the period between the implantation and the first application of the test compound. 



If the administration of the test compound is by single application and the treatment with the 

 test compound occurs after implantation, inoculation, etc. , the time interval coded in Field R is the 

 period between the implantation and the application of the test compound. If the test compound is 

 administered continuously for a period after the implantation, the interval coded in Field R is the 

 period between the implantation and the beginning of the administration of the compound. (If the test 

 compound is administered continuously beginning at the time of implantation, Field R must be coded 

 with Symbol 1. ) 



3. Time to be coded when the test compound is administered PRIOR to MULTIPLE implants 



If the implantation, inoculation, etc. , is multiple and the administration of the test compound 

 is prior to the implantation, the time interval coded in Field R is the period between (1) the last dose 

 (when multiple doses of the test compound are given) and the initial implantation, or (2) the single 

 dose and the initial implantation, or (3) the end of a continuous administration and the initial 

 implantation. 



4. Time to be coded when the test compound is administered AFTER MULTIPLE implants 



If the implantation, inoculation, etc. , is multiple and the administration of the test compound 

 is after the implantation, the time interval coded in Field R is the period (1) between the last 

 implantation and the initial dose (when multiple doses of the test compound are given), or (2) between 

 the last implantation and the single dose, or (3) between the last implantation and the beginning of 

 continuous administration. 



5. Symbol 1 



Symbol 1 is used to specify the administration of the test compound at the same time that 

 implantation, inoculation, etc. , occurs. This symbol is also used when the administration of the 

 test compound occurs within an hour before or after implantation, inoculation, etc. Although time 

 periods less than one hour might have been given symbols, they are seldom of sufficient significance 

 to justify it. When the time period is one hour or more, the other code symbols are used. 



6. Instructions for miscellaneous irregular situations 



If data are indefinitely reported (e. g. , ". . . . treated 4 days to 2 weeks after implantation. . . "), 

 code the symbol that represents the average value of the reported range. Record the entire range in 

 the written abstract of the field. 



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