FIELD S-l 



FIELD S-2 



FIELD S-3 



Columns 54, 55, and 56 



ROUTE AND MANNER OF ADMINISTRATION OF: 



(1) INOCULUM OR IMPLANT (FIELD S-l) 



(2) SECONDARY COMPOUND (FIELD S-2) 



(3) TEST COMPOUND (FIELD S-3) 



Organization 



Although each of these three coding fields is used for recording a unique aspect of chemical- 

 biological tests, basically a single list of items serves to provide symbols for all three. Since only 

 a single IBM column has been provided for each of the fields, only 35 symbols are available. (38 sym- 

 bols might be regarded as being available, if the 0, 11, and 12 zone punches, used alone, were assigned 

 unique Field S meanings. ) 



The arrangement of the items is arbitrary except that, when the list was compiled, those bearing 

 similarities to each other were generally listed together. 



Because certain items are not equally appropriate for all three fields, those symbols are given 

 two or more definitions and where these multiple definitions occur, there is designated by each to 

 which of the three fields, S-l, S-2, or S-3, its use is restricted. 



General Use 



FIELD S-l 



This Field (Column 54) is used for coding the route and manner of administration of the test 

 organism or tumor (specified in Field E), as an inoculum or implant , to the host, living or non-living, 

 specified in Field J. The size of this inoculum or implant (i. e. , the number of individuals of the test 

 organism or the number of tumor cells, when this is estimated) is coded in Field Q. 



FIELD S-2 



In this field (Column 55) is coded the route and manner of administration of a secondary 

 compound (specified in Field D) to the test organism or to the host (either a living or non-living host)-- 

 when this secondary compound is administered in the identical experiment in which the test compound 

 Is administered so that the interaction of the two compounds on the organism is evaluated (antagonism, 

 synergism, or additive effect, Symbols 8, 9, and C of Field T-l). (Field S-2 could be used when 

 Symbol A [simulation] is coded in Field T-l, if the route of administration of the secondary compound 

 simulated were stated by the author, even though the administration of the secondary compound is not 

 in the same test as that of which the results are being coded. ) In other words, Field S-2 is not 

 invariably used when there is an entry in Field D, but only under the circumstances just described; 

 to be specific, it is not used when the entry in Field D is merely a standard of comparison or when it 

 is a compound whose metabolic fate is affected by the test compound. 



When a compound is coded in Field D as a standard whose action is compared to the test 

 compound's action, it would be assumed that that standard, if it were truly eligible for comparison, 

 had been administered (in those tests demonstrating its action) by the same route and manner as the 

 test compound (in the test being coded) or that any difference in the routes of administration of the two 

 compounds had no significant effect on the outcome of the tests of the two compounds. Therefore, since 

 there is no need for such distinction, no provision has been made in the CBCC Biology Code, in Field 

 S-2 or elsewhere, to indicate the route and manner of administration of a standard compound. 



108 



