FIELDS S-l, S-2, and S-3 



Columns 54, 55, and 56 



FIELD S-3 



Field S-3 (Column 56) is used for coding the route and manner of administration of the test 

 compound to the test organism or, if Field J is coded, to the host. In chemotherapy studies, when the 

 test organism, tumor, or pathology (in Field E) is always in a host (Field J), it follows that, under 

 those conditions, the coding in Field S-3 ordinarily describes administration of the test compound to 

 that host. In such tests, if the administration is actually directly to the test organism or tumor rather 

 than directly to the host coded in Field J, the coding of Field S-3 will apply to the test organism. 

 Unfortunately, the CBCC coding of Field S-3 can not distinguish this fact and only by the general 

 sense of the Field S-3 entry and by reference to the written abstract for Field S-3 can it be distinguished 

 that the route coded refers to direct administration to the test organism or tumor. This is discussed also 

 In Division 2 of the Specific Directions and Explanations for Field S-3 . (Three of the items of Field S-3, 

 Symbols J, M, N, and R, invariably imply the test organism's being in or on a non-living host to which 

 the test compound is administered and which is always recorded in Field J; i. e. , Symbols J, M, N, and 

 R are restricted to reference to Field J by their definitions, so with these symbols there is no question 

 as to whether the Field S-3 coding refers to the test organism or tumor in Field E or to the host in 

 Field J. ) 



Specific Directions and Explanations 

 FIELD S-l 



1. Tumor transplants 



In cancer studies, a tumor transplanted into another animal is commonly introduced subcu- 

 taneously. If the author has not specified its transplant location as being elsewhere, the CBCC 

 assumes it is subcutaneous and codes it with Symbol 8. 



2. Relationship of Field S-l with Fields H-l, H-2, and I 



Field S- I is not conceived as having a direct relationship to Fields H-l, H-2, and I. Although 

 most frequently the site of administration of an inoculum (Field S-l) is also the site at which the 

 inoculum (the test organism or tumor) establishes (Fields H and I), it is not invariably the case. Fields 

 H-l and I are always used for coding the location of the test organism or tumor at the time of the test, 

 when a host organism is coded in Field J, and never for coding the site of administration of the test 

 organism or tumor; if the site of administration of the inoculum or implant (the test organism or tumor) 

 is identical to the location of the test organism at the time of the test, it is only coincidental. Neither 

 is Field H-2 used for coding sites of administration of inocula and tumors, but only for coding structures 

 as described in the section discussing Field H-2. 



FIELD S-2 



1. Use of Field S-2 is restricted to secondary compounds with which the test compound 

 interacts, as signaled by certain symbols of Field T- 1 



This has been explained in the section on General Use of Field S-2, above. When Symbol 8, 

 9, or C is used in Field T-l, Field S-2 can be used; otherwise, Field S-2 is always to be left uncoded. 



2. Secondary compounds can be administered to hosts as well as to test organisms; use 

 of Field S-2 when Field J is coded with a host 



Inasmuch as the test compound may antagonize, synergize, or have an additive effect on the 

 therapeutic activity of a secondary compound. Field S-2 may be used when Field J is coded with a host 

 organism- -or even with a non-living host (e. g. , Symbols J, M, and N of Field S-2). Thus, whenever 

 Field J has an entry, any coding in Field S-2 is to be interpreted as being the route or manner of admin- 

 istration of the secondary compound to the host coded in Field J. Just as the test compound may in an 

 occasional test be applied directly to the test organism even when it is on a host (coded in Field J), so 

 Is it possible that the secondary compound might be administered directly to the test organism when the 

 test organism is on a host coded in Field J. Coding of Field S-2 can not distinguish, any more than 



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