FIELDS S-l, S-2, and S-3 

 Columns 54, 55, and 56 



can coding of Field S-3, whether the test organism or the host organism is referred to by the route 

 indicated. (See the section on General Use of Field S-3. ) 



3. Relationship of Field S-2 with Fields H-l, H-Z, and I 



Since Fields H-l and I always are used to code the specifically responding structure of the 

 test organism (when Field J is not coded with a host organism) or are used to code the site of the 

 pathogen or pathology as coded in Field E (when Field J _is coded with a host organism), those anatomy 

 fields can not be used specifically to indicate the structure serving as the route of administration of 

 the secondary compound. Neither can Field H-2 be used for this purpose, because it is reserved for 

 describing the site of administration of the test compound, if this site is not the same as the site of 

 response and if Field H-2 is not otherwise used. (See the description of Field H-2. ) 



FIELD S-3 



1. Relationship of Field S-3 and Fields E and J 



The use of Field S-3 is described above in the section on General Use. When Field J is not 

 coded, a code entry in Field S-3 represents the route and manner of administration of the test compound 

 to the test organism in Field E. When Field J is coded, a code entry in Field S-3 always represents 

 the route and manner of administration of the test compound to the host organism or inanimate host in 

 Field J, unless the written abstract of Field S-3 indicates that administration was essentially directly 

 to the test organism even though a host is coded in Field J, as described in the last paragraphs of the 

 next Division. 



2. Relationship of Field S-3 and Fields M and N and the relation of each of Fields S-3 and 

 Fields M and N to Fields E and J 



The use of IBM 11 and zone punches in Fields M and N (Code Symbols # and 0) is described 

 in Divisions 5, 6, 7, 8, and 9 of the Specific Directions and Explanations of Fields M and N. 



The IBM zone punches in Columns 46 and 48 do not alter the meaning of the coding in Field S-3. 

 In Field S-3 is coded the technique of administration (i. e. , route and manner). The zone punches of 

 Fields M and N designate to which of two or three biological units (the host, or the test organism, or 

 the responding organ or tissue) the test compound was exposed at the dose level coded in Fields M 

 and N, regardless of the technique (route and manner) of administration. 



For example, with the 12 zone punch (Symbol #) in Column 46 or 48, and with Field J coded, the 

 dosage is the amount or concentration to which the test organism was exposed rather than the dosage 

 administered to the host organism. This, however, is not synonymous with saying that the technique 

 of administration (route of administration) has been likewise altered; in the example above, the actual 

 route of administration (Field S-3) might have been directly to the host (Field J), in spite of the fact 

 that the final concentration, as coded in Field M or N was determined as being the one to which the 

 test organism was exposed, after distribution through the host. The zone punches in Columns 46 and 

 48 should not be considered to infer the actual route of administration which is coded only by Field 

 S-3. In view of the foregoing, the coding in Field S-3 should follow the explanation as given above 

 in Division 1, so that it describes only the technique of administration of the test compound. For 

 example, aphids (Field E) on the leaves of rooted willow branches (Field J) were exposed to the test 

 compound at Z ppm in the leaves (Field M, coded with Symbol #) when application was to the branches 

 at 1 10 x Z ppm as a water solution in which the branches were placed (Field S-3, Symbol D). In this 

 example, the route of administration (as coded in Field S-3) was to the host , in spite of Fields M and 

 N indicating (by Symbol #) that the coded dosage was that to which the test organism was exposed. 



If there is an entry in Field J and the test procedure describes the administration as being actually 

 directly to the test organism, the CBCC Code has no way of coding this distinction specifically in 

 Field S-3; it must, however, be adequately explained in the written abstract of Field S-3. Consider 

 the following three situations for illustration: (1) the application of a fumigant or a spray of the test 

 compound (Field S-3, Symbol J or K) at X ppm to aphids (Field E) on leaves of willow branches (Field J); 

 (2) the application of the test compound at X ppm directly onto the abdomen (Symbol G of Field S-3) of 

 a tick (Field E) whose forebody is buried in the skin of a dog (Field J), or (3) the direct exposure of 

 ectoparasites (Field E) on a fish (Field J) to the test compound at X ppm in the water (Symbol N of 



110 



