FIELD T- 1 

 Column 57 



SPECIFIC ACTION OF THE TEST COMPOUND 



ON THE BIOLOGICAL STATE, QUALITY, OR PROCESS 



CODED IN FIELD T-2 



Organization 



Twenty-five items have been listed and assigned code symbols in Field T-l. In constructing 

 this list, the arrangement of the test compound actions has followed no special pattern. 



General Use 



Field T-l is used to describe the test compound's action on the biological state, quality, 

 or process coded in Field T-2 (or the action for which the compound is tested , even though the 

 compound proved inactive). This general use of Field T-l is further distinguished in the previous 

 section discussing Field T as a whole. 



Specific Directions and Explanations 



1. Relations of Field T-l to Field T-2 



None of the items of Field T- 1 represents an independently complete code statement. Exam- 

 ination of the terms defining symbols of Field T-l will make clear that the Field T-l entry must be 

 accompanied by an entry in Field T-2 to form a complete code statement of the test compound's effect 

 on the biological system or of the test organism's effect on the test compound. EVERY LINE OF CODED 

 BIOLOGY DATA DEMANDS AN ENTRY IN BOTH FIELD T-l AND FIELD T-2. 



2. Action of the test compound on the biological system vs. action of the biological system on 

 the test compound 



Most of the terms of Field T-l describe actions of the test compound on the biological system 

 to which it has been administered. Certain tests, however, reveal the fate of the chemical itself 

 instead of. or in addition to, the organism's specific response to it. For example, the biological 

 system may store the compound, absorb it, alter it, etc. The terms of Field T-2 which describe these 

 actions on the test compound are indicated by Symbols F9B, FAB, FBB, FGB, FIB, and any of the 

 Symbol series FE-- and FF-B. 



With any of the Field T-2 terms above (coding the action of the biological system on the test 

 compound), Field T-l is coded with Symbol 7. When used with these Field T-2 terms, Symbol 7 

 represents the term "undergoes" or "is", indicating the test compound's being acted on. With all 

 other Field T-2 terms, Symbol 7 represents "causes", "produces", "induces", etc. 



3. Field T-l coding is NOT influenced by the test result being NEGATIVE 



In collecting and recording chemical- biological data for future retrieval and study, it is as 

 important to code specifically those actions which test compounds have been demonstrated unable to 

 perform as it is to code those which test compounds have been demonstrated capable of performing. 

 Therefore, when a test is run specifically to determine whether a chemical will perform a given action 

 (or whether the chemical will be altered or otherwise affected in a given way by the test organism) 

 and the chemical proves to be inactive (or to be unaffected by the test organism), Field T-l can not 

 express the fact that the specific action was not produced (or that the test compound had not been 

 affected by the test organism). The code statement of Field T (including Field T-l) is always positive; 

 if the data are negative, the negation of the Field T statement is accomplished by code only in 

 Fields X and Y. 



114 



