FIELD T-l 

 Column 57 



In Division 5 below, a slight variance in coding of Field T-l for special negative data is 

 discussed. 



4. Field T- 1 coding IS influenced by the test result being the REVERSE of an action for which 

 the compound was tested 



When a test compound has been administered in an effort to induce or affect in a given way a 

 specific biological condition or process of Field T-2, the compound may prove to do the reverse (e. g. , 

 it prevents instead of induces or it decreases instead of increases the state or process in Field 

 T-2). In this case, Field T-l must be coded to record the action actually demonstrated; subsequently, 

 it would be meaningless to construct a second line in which Field T-l would be coded with the action 

 for which the test was made and negate it by coding in Fields X and Y. 



5. Coding of Field T-l when a compound is tested for action on a specific biological state 

 or process (coded in Field T-2), and the following factors all apply: (1) the state or 

 process in Field T-2 is one that might be affected in either of two opposing ways, (2) the 

 compound proved inactive, and (3) the author does not state for which of the two opposing 

 actions the compound had been tested 



Under these conditions, the CBCC avoids coding arbitrarily the compound's failure to accomplish 

 one or the other of the two possible effects on the condition or process coded in Field T-2. Instead, 

 both are coded. In essence, this would involve two biology code lines, one with Field T-l coded 

 with one action (e. g. , increase), the other with Field T-l coded with the opposing action (e. g. , 

 decrease); in actual practice, however, the CBCC conserves space and coding time by combining the 

 two lines, accomplished by coding both actions in Field T-l in the same line . 



An exception to combining these two lines into one must be made in the case of the specific 

 states indicated by Symbols of the two series, 171- and 161-, of Field T-2 (the number of pathogenic 

 organisms having been diminished or increased). The association of alteration of the number of 

 organisms with improving or exacerbating an infectious pathology necessitates defining those Field 

 T-2 symbols as either being a state of diminished numbers of organisms or of increased numbers of 

 organisms and Field T-l is consequently coded with Symbol 7 to indicate that the state of diminished 

 or increased numbers has been "caused". Since Field T-2 can never have more than one entry, two 

 separate lines are necessary for this. 



It might be pointed out here that when the author reports the test compound as having no effect 

 and in addition does not indicate any specific biological state or process that was being treated 

 or initiated (so that there is no specific entry for Field T-2), Field T-l can be coded only with 

 Symbol 0. (See Division 18 below. ) 



6. Symbols 1 and 2; quantitative change or change of rate (exclusive of total abolishment or 

 prevention) of the biological state or physiological process coded in Field T-2 



These symbols are each given two meanings, though the sense of increase is implicit in both 

 of the definitions for Symbol 1 and the sense of decrease is implicit in both of those for Symbol 2. 



Symbol 1; (a) increases 



(b) accelerates 

 Symbol 2: (a) decreases 



(b) slows 



Thus, these two symbols can be used for coding the action of the test compound in increasing 

 or decreasing size , number , or degree (e. g. , increasing or decreasing the number of fruits [Field T-2, 

 Symbol 191], nuclear size [Symbol 225], number of blood cells [Symbol 851], organism weight [Symbol 

 2A1], prothrombin time [Symbol 8731], or circulatory rate [Symbol C6]), which represents a quantitative 

 effect only. However, the symbols are used also for coding the action of the test compound in increas- 

 ing or decreasing the rate of any physiological process which is not defined in Field T-2 as a rate 

 (e. g. , accelerating or slowing the alteration of the test compound [Field T-2 Symbol series FE--], 

 spiracular movement [Symbol B2], sol-gel transformation [Symbol 833], regional growth [Symbol 2A4]). 



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