FIELD T-l 

 Column 57 



In sorting the coded files for data on specific action of compounds, it is possible that one 

 might want to retrieve data on all compounds that (e. g. ) increased a state or physiological process, 

 regardless of whether it was or was not increased from the normal level . If such were the case, it 

 would be somewhat advantageous if, for all instances of increase of the state or process, Field T-l 

 were coded with Symbol 1, rather than having to sort out all that data for which Field T-l was coded 

 with Symbols J, M, and Q, as well as that data for which Field T- 1 was coded with Symbols 1 and 2. 

 However, in most cases, retrieval of data on all compounds that increase or speed a state or physio- 

 logical process is preferably limited to those data in which the effect was an increase or acceleration 

 from a normal level; i. e. , it is preferred not to have included, with that retrieved data, information on 

 compounds which merely corrected a state or process pathologically diminished or which exacerbated 

 a state or process pathologically increased or accelerated . For this reason, it is useful to have the 

 two types of data distinguished; thus, when retrieving information on increase or acceleration of a 

 state, quality, or process from a normal level, omission of any data on increase or acceleration from 

 a pathological level can be accomplished by eliminating any Field T-2 items identified as pathologies 

 associated with the state, quality, or process concerned in the search and by elimination of any infor- 

 mation coded with Symbol J, M, or Q in Field T-l. 



In summary, when Field E is coded with a pathology and a symptom of the pathology is coded 

 in Field T-2, Field T-l is coded with Symbol 1 or P, Q, or R; 2 or M, N, or 0; or 3 or J, K, or L, 

 according to the character of the Field T-2 term. If the Field T-2 term is identifiable by its definition 

 as a pathological state or process, Field T-l is coded with Symbol 1 or 2 (or Symbol 3, if the patho- 

 logical state or process is abolished- -i. e. , if a cure is effected). If the Field T-2 term representing 

 a pathological symptom is identifiable only as a normal state or process, Field T-l must be coded with 

 Symbol J, K, L, M, N, 0, P, Q, or R. This is discussed more thoroughly in Divisions 16 and 17 which 

 explain in more detail the specific use of Symbols J through R. 



8. Symbol 3; complete abolishment or prevention of a normal or pathological biological state 

 or physiological process coded in Field T-2 



When a test compound stops or prevents or is tested to stop or prevent a specific normal 

 biological state or physiological process, Symbol 3 Is used in Field T-l and evaluation (Field Y) 

 is based on the ability of the test compound to stop or prevent the normal state or process, rather 

 than on the ability to cause some degree of decrease or slowing of the normal state or process. 



However, when a test compound stops or prevents a specific pathological biological state or 

 physiological process, the action is coded in Field T-l with Symbol 3 only with certain Field T-2 

 entries; with other Field T-2 entries, Field T-l must be coded with Symbol J, K, or L, as explained 

 in the following paragraphs. 



In Division 7, Field T-2 terms were described as being of two major types, one being of 

 normal states or processes (e. g. , number of flowers, Symbol 191; nuclear shape, Symbol 226; 

 regeneration, Symbol 272), referred to in the first paragraph of the present discussion. The other 

 type was described as consisting of pathological states or processes coded in Field T-2 (e. g. , local 

 toxicity, Symbol 113; atrophy, Symbol 411). 



When a compound is administered to affect (rather than "cause", Symbol 7 of Field T-l) one 

 of those pathological states or processes coded in Field T-2 as a term of the second type, that effect 

 can be coded with Symbol 1 or 2, or if the pathological state or process is wholly abolished ( cured ) 

 or prevented, the action can be coded with Symbol 3 . 



However, if a symptom (coded in Field T-2) of a pathology (coded in Field E) can be identified 

 in Field T-2 only as a normal biological state or physiological process (i. e. , if there is no indication 

 in Field T-2 that the normal state or process has been rendered abnormal by the pathology in Field E) 

 and the test compound is administered to affect that pathologically altered state or process, Symbol 3 

 can not be used if the compound returns the state or process to complete normalcy, because it would 

 only be interpreted as having abolished or prevented the normal state or process. 



As was pointed out in Division 7, when a pathology symptom is coded in Field T-2 only as the 

 normal state or process which has been altered by the pathology, the special symbols J, K, and L 

 must be used in Field T-l instead of Symbol 3. 



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