FIELD T-l 

 Column 57 



Symbols of the 16-- and 17-- series of Field T-2 are used when a pathology is coded in Field E, 

 but they are somewhat unique in that they do not represent a pathological state (i. e. , they do not 

 represent a symptom of the pathology coded in Field E). Instead, they represent a state (e. g. , "cure", 

 "restraint", or "intensification") or symptom (e. g. , "reduction [or increase] of the number of pathogen 

 individuals") of recovery from or of exacerbation of the general pathology coded in Field E. With any 

 of these symbols in Field T-2, Symbol 7 is used in Field T-l, even though Field E is coded with a 

 pathology, to code the test compound's "bringing about" that state of recovery or exacerbation. 



Symbol 7 is used to describe what is essentially an action of the biological system on the test 

 compound (rather than an action of the test compound on the biological system), a use which is 

 described in Division 2. This represents an exception to the general rule that Symbol 7 is never used 

 when Field T-2 is coded with a symbol defined as a normal physiological process. These Field T-2 

 items deal with the alteration of the test compound or a secondary compound by the biological system 

 (Symbol series FE--) or with the synthesis or metabolic fate of the test compound or secondary compound 

 (Symbol series F6--, F8--, F9--, FA--, FB--, FC--, FF--, FG--, FH--, andFI--). 



When the test compound has been altered, synthesized, or metabolized, Field T-2 is coded with 

 the appropriate term (FE--, FAB, FBB, FGB, FIB, or FF-B) and Symbol 7 is used in Field T-l to mean 

 that the test compound "is oxidized", or '4s excreted" or "ij> stored", etc. (i. e. , "undergoes oxidation" 

 or " undergoes excretion" or " undergoes storage", etc. ) by the normal organism coded in Field E. 



When the test compound affects the alteration, synthesis, or metabolism of a secondary 

 compound, Field T-2 is coded with the appropriate term (FE-- with an asterisk in Column 61, F6-, F9-, 

 FA-, FB-, FG-, FH-, FI-, or FF--) and Field T- 1 is ordinarily coded with Symbol 1, 2, or 3, since the 

 affect is generally one of increase, decrease, or arrest. However, it is possible that the test compound 

 may initiate or permit the alteration, synthesis, or metabolism of the secondary compound and for this 

 Symbol 7 would be used. 



12. Symbols 8, 9, and C; coding of the test compound's influence (Field T-l) on the action (not 

 coded) of another compound (Field D) on a biological state or physiological process 

 (Field T-2); depression ("antagonism") or enhancement (either "synergism" or simple "additive 

 effect"); Symbols 9, 8, and C, respectively 



Five general aspects of experimental data demonstrating synergism, antagonism, or additive 

 effect (Symbols 9, 8, and C) are dealt with in this division. (A related aspect, which might be con- 

 sidered a sixth, is that concerned with coding of a test compound's being essential for or permitting 

 the action of a secondary compound, coded by Symbol 8; to avoid making further complex the distinc- 

 tions made here in Division 12, this matter is discussed separately as Division 13. ) These five are: 



(1) Definitions, according to which the test compound's effect can be distinguished as one 

 or the other of antagonism, synergism, or additive effect. 



(2) Determination of which compound, of the two compounds involved in such investigations, 

 should be coded as the test compound and which should be coded as the secondary compound. 



(3) The use of Field T-l to code these effects on the action of a second compound, a use 

 which prevents coding that action affected. This problem includes the aspects of 

 preparing code lines for recording the action antagonized , synergized , or supplemented , 

 as well as the action of the antagonist , synergist , or additive agent when administered 

 alone. 



(4) Coding when a compound is tested to affect (synergize, antagonize, or be additive in 

 affecting) the synergistic or antagonistic effect of a secondary compound on a third 

 compound's action on the biological state or physiological process coded in Field T-2. 

 This coding procedure is dependent on factors and procedures related to the third aspect 

 above. 



(5) The criteria (Field X) by which each of these three influences of test compounds (on actions 

 of secondary compounds) can be evaluated (Field Y). 



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